miR-132 can inhibit glioma cells invasion and migration by target MMP16 in vitro

Gliomas are the most common malignant primary brain tumors, and new clinical biomarkers and therapeutic targets are imminently required. MicroRNAs (miRNAs) are a novel class of small non-coding RNAs (∼22nt) involved in the regulation of various biological processes. Here, by using real-time polymera...

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Bibliographic Details
Published in:OncoTargets and therapy 2015-01, Vol.8, p.3211-3218
Main Authors: Wang, Hangzhou, Li, Xue-Tao, Wu, Chun, Wu, Zhi-Wu, Li, Yan-Yan, Yang, Tian-Quan, Chen, Gui-Lin, Xie, Xue-Shun, Huang, Yu-Lun, Du, Zi-Wei, Zhou, You-Xin
Format: Article
Language:English
Subjects:
Alzheimer's disease
Bone cancer
Brain cancer
Brain research
Cancer therapies
Cell adhesion & migration
Cell growth
Development and progression
Gastric cancer
Gene expression
Genetic aspects
Genetic regulation
Glioma
Gliomas
Health aspects
Innovations
Liver cancer
Medical prognosis
Melanoma
Metastasis
MicroRNA
MicroRNAs
Molecular targeted therapy
Neurosurgery
Original Research
Properties
Prostate cancer
Proteases
Proteins
Tumors
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Summary:Gliomas are the most common malignant primary brain tumors, and new clinical biomarkers and therapeutic targets are imminently required. MicroRNAs (miRNAs) are a novel class of small non-coding RNAs (∼22nt) involved in the regulation of various biological processes. Here, by using real-time polymerase chain reaction, miRNA-132 was found to be significantly deregulated in glioma tissues. Based on the prediction of the target genes of miR-132, we hypothesized that there is a significant association between miR-132 and matrix metalloproteinase (MMP) 16 (MT3-MMP), a protein of the MMP family. We showed that the up-expression of miR-132 inhibited cell migration and invasion in the human glioma cell lines A172, SHG44, and U87. Furthermore, the overexpression of miR-132 reduced the expression of MMP16 in A172, SHG44, and U87 cells. Taken together, our study suggested that miR-132 affects glioma cell migration and invasion by MMP16 and implicates miR-132 as a metastasis-inhibiting miRNA in gliomas.
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S79282