Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occurring resorcinolic macrolides

• Published in: Acta pharmacologica Sinica 2014-03, Vol.35 (3), p.316-330
• Main Authors: Xu, Jing, Jiang, Cheng-shi, Zhang, Zai-long, Ma, Wen-quan, Guo, Yue-wei
• Format: Article
• Language: English
• Subjects: Animals; Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - metabolism; Anti-Infective Agents - pharmacology; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - metabolism; Antineoplastic Agents - pharmacology; Biomedical and Life Sciences; Biomedicine; Humans; Immunology; Internal Medicine; Macrolides - chemical synthesis; Macrolides - isolation & purification; Macrolides - metabolism; Macrolides - pharmacology; Medical Microbiology; Molecular Structure; Pharmacology/Toxicology; Resorcinols - chemical synthesis; Resorcinols - isolation & purification; Resorcinols - metabolism; Resorcinols - pharmacology; Review; Structure-Activity Relationship; Vaccine; 化学合成; 大环内酯类药物; 天然产物; 抗肿瘤; 生物合成; 生物活性; 自然; 间苯二酚
• ISSN: 1671-4083; 1745-7254
• DOI: 10.1038/aps.2013.155

Macrolides, which comprise a family of lactones with different ring sizes, belong to the polyketide class of natural products. Resorcinolic macrolides, an important subgroup, possess interesting structures and exhibit a wide variety of bioactivities, such as anti- tumor, anti-bacteria, and anti-malaria activities, etc. This review summarizes progress in isolation, bioactivity studies, biosynthesis, and representative chemical syntheses of this group of macrolides in recent decades, encompassing 63 naturally occurring macrolides published in 120 articles.