Aquaporin-dependent excessive intrauterine fluid accumulation is a major contributor in hyper-estrogen induced aberrant embryo implantation

Dear Editor, In mammalian species, the window of implantation is defined as a limited period when implantation-competent blastocyst can interact with the receptive endometrium [1]. Besides the acquisition of blastocyst competency and uterine receptivity, initiation of embryo implantation also involv...

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Bibliographic Details
Published in:Cell research 2015-01, Vol.25 (1), p.139-142
Main Authors: Zhang, Ying, Chen, Qi, Zhang, He, Wang, Qiang, Li, Rong, Jin, Yaping, Wang, Haibin, Ma, Tonghui, Qiao, Jie, Duan, Enkui
Format: Article
Language:English
Subjects:
692/700/139
692/700/565/1783
Abortion, Spontaneous - etiology
Abortion, Spontaneous - metabolism
Animals
Aquaporins - metabolism
Biomedical and Life Sciences
Cell Biology
Embryo Implantation
Estrogens
Estrogens - administration & dosage
Estrogens - metabolism
Female
Letter to the Editor
Life Sciences
Litter Size
Mice
Pregnancy
Uterus - metabolism
Uterus - pathology
子宫内膜
异常
水通道蛋白
积液
胚胎植入
诱导
过度
雌激素
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Summary:Dear Editor, In mammalian species, the window of implantation is defined as a limited period when implantation-competent blastocyst can interact with the receptive endometrium [1]. Besides the acquisition of blastocyst competency and uterine receptivity, initiation of embryo implantation also involves a timely reabsorption of intrauterine fluids, which facilitates the apposition of embryo with the uterine lining [2]. These processes are coordinated by
ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2014.139