The role of nodose ganglia in the regulation of cardiovascular function following pulmonary exposure to ultraffine titanium dioxide

The inhalation of nanosized air pollutant particles is a recognised risk factor for cardiovascular disease; however, the link between occupational exposure to engineered nanoparticles and adverse cardiovascular events remains unclear. In the present study, the authors demonstrated that pulmonary exp...

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Bibliographic Details
Published in:Nanotoxicology 2013-05, Vol.8 (4), p.447-454
Main Authors: Kan, Hong, Wu, Zhongxin, Lin, Yen-Chang, Chen, Teh-Hsun, Cumpston, Jared L, Kashon, Michael L, Leonard, Steve, Munson, Albert E, Castranova, Vincent
Format: Article
Language:English
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Summary:The inhalation of nanosized air pollutant particles is a recognised risk factor for cardiovascular disease; however, the link between occupational exposure to engineered nanoparticles and adverse cardiovascular events remains unclear. In the present study, the authors demonstrated that pulmonary exposure of rats to ultrafine titanium dioxide (UFTiO 2 ) significantly increased heart rate and depressed diastolic function of the heart in response to isoproterenol. Moreover, pulmonary inhalation of UFTiO 2 elevated mean and diastolic blood pressure in response to norepinephrine. Pretreatment of the rats ip with the transient receptor potential (TRP) channel blocker ruthenium red inhibited substance P synthesis in nodose ganglia and associated functional and biological changes in the cardiovascular system. In conclusion, the effects of pulmonary inhalation of UFTiO 2 on cardiovascular function are most likely triggered by a lung-nodose ganglia-regulated pathway via the activation of TRP channels in the lung.
ISSN:1743-5390
1743-5404
DOI:10.3109/17435390.2013.796536