Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer

BACKGROUND Chloride channel accessory 1 (CLCA1) is a CLCA protein that plays a functional role in regulating the differentiation and proliferation of colorectal cancer (CRC) cells. Here we investigated the relationship between the level of CLCA1 and the prognosis of CRC. METHODS First, the level of...

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Bibliographic Details
Published in:Cancer 2015-05, Vol.121 (10), p.1570-1580
Main Authors: Yang, Bo, Cao, Lin, Liu, Jiaen, Xu, Yanjie, Milne, Gillian, Chan, Wanhei, Heys, Steven D., McCaig, Colin D., Pu, Jin
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - metabolism
Blotting, Western
Cadherins - metabolism
cell differentiation
chloride channel accessory 1 (CLCA1) expression
Chloride Channels - metabolism
colorectal carcinoma
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Down-Regulation
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Ki-67 Antigen - metabolism
Male
Middle Aged
Neoplasm Grading
Neoplasm Staging
Original
Predictive Value of Tests
Prognosis
PTEN Phosphohydrolase - metabolism
Tumor Suppressor Protein p53 - metabolism
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Summary:BACKGROUND Chloride channel accessory 1 (CLCA1) is a CLCA protein that plays a functional role in regulating the differentiation and proliferation of colorectal cancer (CRC) cells. Here we investigated the relationship between the level of CLCA1 and the prognosis of CRC. METHODS First, the level of CLCA1 was detected quantitatively in normal and cancerous colonic epithelial tissues with immunohistochemistry. Next, the correlations between CLCA1 expression, pathological tumor features, and the overall survival rate of patients was analyzed. Finally, 3 publicly available data sets from the Gene Expression Omnibus were examined: normal CRC versus early CRC (GSE4107), primary CRC versus metastatic lesions (GSE28702), and low chromosomal instability versus high chromosomal instability (GSE30540). RESULTS The expression of CLCA1 was decreased markedly in tumor specimens. CLCA1 expression was correlated significantly with the histological grade (P 
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.29235