A sunblock based on bioadhesive nanoparticles

The majority of commercial sunblock preparations use organic or inorganic ultraviolet (UV) filters. Despite protecting against cutaneous phototoxicity, direct cellular exposure to UV filters has raised a variety of health concerns. Here, we show that the encapsulation of padimate O (PO)—a model UV f...

Full description

Saved in:
Bibliographic Details
Published in:Nature materials 2015-12, Vol.14 (12), p.1278-1285
Main Authors: Deng, Yang, Ediriwickrema, Asiri, Yang, Fan, Lewis, Julia, Girardi, Michael, Saltzman, W. Mark
Format: Article
Language:English
Subjects:
639/166/985
639/301/54/152
Adhesion
Animals
Biomaterials
Biomedical engineering
Cellular
Condensed Matter Physics
Deoxyribonucleic acid
DNA
Drug delivery systems
Drying
Encapsulation
Exposure
Filters
Materials Science
Mice
Nanoparticles
Nanotechnology
Optical and Electronic Materials
Phototoxicity
Skin - drug effects
Skin - metabolism
Sunscreen
Sunscreen products
Sunscreening Agents - metabolism
Sunscreening Agents - pharmacology
Ultraviolet Rays
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The majority of commercial sunblock preparations use organic or inorganic ultraviolet (UV) filters. Despite protecting against cutaneous phototoxicity, direct cellular exposure to UV filters has raised a variety of health concerns. Here, we show that the encapsulation of padimate O (PO)—a model UV filter—in bioadhesive nanoparticles (BNPs) prevents epidermal cellular exposure to UV filters while enhancing UV protection. BNPs are readily suspended in water, facilitate adherence to the stratum corneum without subsequent intra-epidermal or follicular penetration, and their interaction with skin is water resistant yet the particles can be removed via active towel drying. Although the sunblock based on BNPs contained less than 5 wt% of the UV-filter concentration found in commercial standards, the anti-UV effect was comparable when tested in two murine models. Moreover, the BNP-based sunblock significantly reduced double-stranded DNA breaks when compared with a commercial sunscreen formulation. A water-resistant sunblock based on bioadhesive nanoparticles encapsulating a model ultraviolet filter at low concentrations adheres to the stratum corneum without subsequent intra-epidermal or follicular penetration.
ISSN:1476-1122
1476-4660
DOI:10.1038/nmat4422