Effect of Diet and Exercise on the Peripheral Immune System in Young Balb/c Mice

Although diet and exercise clearly have an influence on immune function, studies are scarce on the effect caused by exercise and the consumption of a carbohydrate-rich or fat-rich diet on the peripheral immune system. The aim of the present study was to evaluate the effect of exercise and the two af...

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Bibliographic Details
Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-13
Main Authors: Valdés-Ramos, Roxana, Campos-Rodriguez, Rafael, Jarillo-Luna, Rosa Adriana, Martínez-Carrillo, Beatríz E., Rivera-Aguilar, V.
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - immunology
Body Mass Index
Carbohydrates
Cytokines
Cytokines - immunology
Diet
Diet - methods
Eating - immunology
Exercise
Fatty acids
Health aspects
Immune system
Immunity, Innate - immunology
Laboratory animals
Lipids
Lymphocytes
Male
Mice
Mice, Inbred BALB C
Motor Activity - immunology
Oxidative stress
Physical Conditioning, Animal - methods
Physical fitness
Physiological aspects
Population
Proteins
Rodents
Studies
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Summary:Although diet and exercise clearly have an influence on immune function, studies are scarce on the effect caused by exercise and the consumption of a carbohydrate-rich or fat-rich diet on the peripheral immune system. The aim of the present study was to evaluate the effect of exercise and the two aforementioned unbalanced diets on young Balb/c mice, especially in relation to BMI, the level of glucose, and the percentage of lymphocyte subpopulations in peripheral blood. The changes found were then related to the synthesis of leptin and adiponectin as well as the production of oxidative stress. The increase in BMI found with the carbohydrate-rich and fat-rich diets showed correlation with the levels of leptin and adiponectin. An increase in leptin and a decrease in adiponectin directly correlated with an increase in total lymphocytes and CD4+ cells and with a decrease in B cells. The increase in leptin also correlated with an increase in CD8+ cells. Glycemia and oxidative stress increased with the two unbalanced diets, negatively affecting the proliferation of total lymphocytes and the percentage of B cells, apparently by causing alterations in proteins through carbonylation. These alterations caused by an unbalanced diet were not modified by moderate exercise.
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/458470