Expression and Prognostic Significance of Macrophage Inflammatory Protein-3 Alpha and Cystatin A in Nasopharyngeal Carcinoma

This study aims to investigate the expression of macrophage inflammatory protein-3 alpha (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) and their association with clinical characteristics and prognosis. Primary tumor specimens from 114 NPC patients and associated clinical follow-up data w...

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Bibliographic Details
Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-6
Main Authors: Cai, Yonglin, Zheng, Yuming, Zhong, Weiming, Ma, Liping, Li, Jun, Lu, Aiying, Li, Cheng, Ou, Ningjiang, Tang, Minzhong, Gao, Jianquan
Format: Article
Language:English
Subjects:
Adult
Aged
Angiogenesis
Biomarkers, Tumor - metabolism
Biopsy
Cancer therapies
Carcinoma
Cell growth
Chemokine CCL20 - metabolism
Chemokines
Chemotherapy
China - epidemiology
Cystatin A - metabolism
Enzymes
Extracellular matrix
Female
Gene expression
Genetic aspects
Health aspects
Humans
Laboratories
Liver cancer
Lymphatic system
Macrophages
Male
Medical prognosis
Metastasis
Middle Aged
Multivariate analysis
Nasopharyngeal cancer
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - metabolism
Nasopharyngeal Neoplasms - mortality
Nasopharyngeal Neoplasms - radiotherapy
Observations
Prevalence
Prognosis
R&D
Radiation therapy
Reproducibility of Results
Research & development
Risk Assessment - methods
Sensitivity and Specificity
Statins
Survival Rate
Treatment Outcome
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Description
Summary:This study aims to investigate the expression of macrophage inflammatory protein-3 alpha (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) and their association with clinical characteristics and prognosis. Primary tumor specimens from 114 NPC patients and associated clinical follow-up data were collected, and the expression of MIP-3α and cystatin A proteins was investigated by immunohistochemistry. Expression of MIP-3α was significantly associated with TNM stage in patients with NPC (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/617143