Human papillomavirus and Epstein-Barr virus in nasopharyngeal carcinoma in a low-incidence population

Background The significance of human papillomavirus (HPV) in nasopharyngeal carcinomas (NPCs) in a low‐incidence population remains unknown. Methods Samples from 90 patients with NPC (years, 1957–2012) were analyzed for Epstein–Barr virus (EBV). Clinical data, EBV, HPV, and p16 status were correlate...

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Published in:Head & neck 2014-04, Vol.36 (4), p.511-516
Main Authors: Dogan, Snjezana, Hedberg, Matthew L., Ferris, Robert L., Rath, Tanya J., Assaad, Adel M., Chiosea, Simion I.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma - mortality
Carcinoma - virology
Epstein-Barr virus
Epstein-Barr Virus Infections - epidemiology
Female
Herpesvirus 4, Human - genetics
Herpesvirus 4, Human - isolation & purification
human papillomavirus
Humans
Male
Middle Aged
nasopharyngeal carcinoma
Nasopharyngeal Neoplasms - mortality
Nasopharyngeal Neoplasms - virology
Papillomaviridae - genetics
Papillomaviridae - isolation & purification
Papillomavirus Infections - epidemiology
Pennsylvania - epidemiology
Prevalence
Washington - epidemiology
Young Adult
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Summary:Background The significance of human papillomavirus (HPV) in nasopharyngeal carcinomas (NPCs) in a low‐incidence population remains unknown. Methods Samples from 90 patients with NPC (years, 1957–2012) were analyzed for Epstein–Barr virus (EBV). Clinical data, EBV, HPV, and p16 status were correlated with overall survival (OS; 63 cases; years, 1981–2012). Results Of 9 HPV‐positive cases, 3 extended from extra‐nasopharyngeal sites. Nasopharyngeal origin was confirmed in 6 cases. HPV‐positive NPC had OS similar to EBV‐positive NPC (85 vs 141 months; p > .05). The OS of patients with EBV/HPV‐negative NPC was worse (34 months; p = .004). Nonkeratinizing histology was associated with better outcome than keratinizing (115 vs 25 months; p = .001). Over the last several decades, the proportion of keratinizing NPC decreased from 34.5% to 14.3% (p = .026). Conclusion The etiologic role of HPV in NPC is confirmed. The favorable prognostic significance of HPV positivity is similar to that of EBV positivity. © 2013 Wiley Periodicals, Inc. Head Neck 36: 511–516, 2014
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.23318