Characterization of M2 antibodies in asymptomatic Chinese population

AIM: To investigate the presence of M2 antibodies specific for primary biliary cirrhosis (PBC) in asymptomatic Chinese and identify patients with early PBC.METHODS: Enzyme-linked immunosorbent assay (ELISA) tests for M2 antibodies to recombinant protein were performed in 5 011 subjects (age range, 2...

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Published in:World journal of gastroenterology : WJG 2003-09, Vol.9 (9), p.2128-2131
Main Authors: Jiang, Xiao-Hua, Zhong, Ren-Qian, Fan, Xiao-Yun, Hu, Yin, An, Feng, Sun, Jian-Wen, Kong, Xian-Tao
Format: Article
Language:English
Subjects:
Adult
Aged
Alkaline Phosphatase - blood
Autoantibodies - analysis
Brief Reports
Enzyme-Linked Immunosorbent Assay
Female
gamma-Glutamyltransferase - blood
Humans
Liver - pathology
Liver Cirrhosis, Biliary - diagnosis
Liver Cirrhosis, Biliary - immunology
Liver Cirrhosis, Biliary - pathology
Liver Cirrhosis, Biliary - physiopathology
M2抗体
Male
Middle Aged
Mitochondria, Liver - immunology
原发性胆汁性肝硬变
酶链免疫吸附试验
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Summary:AIM: To investigate the presence of M2 antibodies specific for primary biliary cirrhosis (PBC) in asymptomatic Chinese and identify patients with early PBC.METHODS: Enzyme-linked immunosorbent assay (ELISA) tests for M2 antibodies to recombinant protein were performed in 5 011 subjects (age range, 26-85 years; mean age: 45.81±15.02 years) who took an annual physical examination. M2-positive subjects were further analyzed for immunoglobulin (Ig) dasses and subclasses of M2 antibodies.Clinical, biochemical and immunological data were obtained for M2-positive subjects. In addition, ultrasonography (US) or endoscopic rebograde cholangio-pancreatography (ERCP) was performed to exclude any disorders other than PBC.RESULTS: M2 antibodies were detected in 8 (0.16 %) of the 5 011 subjects studied. Of the 8 subjects, 7 were female and 1 was male (age range: 40-74 years). An unexplained increase of serum alkaline phosphatase (ALP) and gamma glutamyl banspeptidase (γ-GT) values, ofcen to striking levels,was detected in 4 M2-positive subjects, 3 of them accorded with the diagnostic criteria recommended by the American Association for the Study of liver Diseases, even though they had no symptoms of PBC (such as fatigue, pruritus or jaundioe).Liver biopsy was performed in two M2-positive subjects and the histology was compatible with PBC in both cases.CONCLUSION: Our data, while not assessing the true prevalence of asymptomatic PBC in the general population,suggest that asymptomatic PBC is much more common in China than has been supposed.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v9.i9.2128