Influence of phenotype conversion of epicardial adipocytes on the coronary atherosclerosis and its potential molecular mechanism

To investigate the phenotype conversion of epicardial adipocytes and its potential molecular mechanism during the occurrence and development of coronary atherosclerosis. A total of 30 health male New Zealand white rabbits were used. In experiment group (n=15), rabbits were fed with high fat food to...

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Published in:American journal of translational research 2015-01, Vol.7 (10), p.1712-1723
Main Authors: Wang, Jing, Chen, Dong, Cheng, Xun-Min, Zhang, Qi-Gao, Peng, Yong-Ping, Wang, Li-Jun, He, Song-Qing, Gong, Jian-Bin
Format: Article
Language:English
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Summary:To investigate the phenotype conversion of epicardial adipocytes and its potential molecular mechanism during the occurrence and development of coronary atherosclerosis. A total of 30 health male New Zealand white rabbits were used. In experiment group (n=15), rabbits were fed with high fat food to establish atherosclerosis animal model; rabbits in control group (n=15) were fed with normal food. At week 0, UCP-1 and PPARĪ³ mRNA expressions in EAT and sBAT were significantly higher than in eWAT, and leptin mRNA expression lower than (P
ISSN:1943-8141
1943-8141