Influence of phenotype conversion of epicardial adipocytes on the coronary atherosclerosis and its potential molecular mechanism

To investigate the phenotype conversion of epicardial adipocytes and its potential molecular mechanism during the occurrence and development of coronary atherosclerosis. A total of 30 health male New Zealand white rabbits were used. In experiment group (n=15), rabbits were fed with high fat food to...

Full description

Saved in:
Bibliographic Details
Published in:American journal of translational research 2015-01, Vol.7 (10), p.1712-1723
Main Authors: Wang, Jing, Chen, Dong, Cheng, Xun-Min, Zhang, Qi-Gao, Peng, Yong-Ping, Wang, Li-Jun, He, Song-Qing, Gong, Jian-Bin
Format: Article
Language:English
Subjects:
Original
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 1723
container_issue 10
container_start_page 1712
container_title American journal of translational research
container_volume 7
creator Wang, Jing
Chen, Dong
Cheng, Xun-Min
Zhang, Qi-Gao
Peng, Yong-Ping
Wang, Li-Jun
He, Song-Qing
Gong, Jian-Bin
description To investigate the phenotype conversion of epicardial adipocytes and its potential molecular mechanism during the occurrence and development of coronary atherosclerosis. A total of 30 health male New Zealand white rabbits were used. In experiment group (n=15), rabbits were fed with high fat food to establish atherosclerosis animal model; rabbits in control group (n=15) were fed with normal food. At week 0, UCP-1 and PPARγ mRNA expressions in EAT and sBAT were significantly higher than in eWAT, and leptin mRNA expression lower than (P
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4656752</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1751489499</sourcerecordid><originalsourceid>FETCH-LOGICAL-p266t-bc198699ece00f74444f3c415ce7a059c1bde97c6c08e84cb70cce344ce823a23</originalsourceid><addsrcrecordid>eNpVUE1LxDAQLaK46-pfkBy9FJo2TZuLIIsfC4IXPZd0OnUjaRKTdGFv_nRbXGWdw3y-efOYk2RJBSvSmjJ6epQvkosQPrKMl4Ln58ki51zkgopl8rUxvR7RABLbE7dFY-PeIQFrduiDsmbuo1MgfaekJrJTzsI-YiDTLG5nqLdG-j2RU-VtAD17FYg0HVExEGcjmjgvD1YjjFp6MiBspVFhuEzOeqkDXh3iKnl7uH9dP6XPL4-b9d1z6iaxMW2BipoLgYBZ1ldssr4ARkvASmalANp2KCrgkNVYM2irDAALxgDrvJB5sUpuf3jd2A7YwaTIS904r4ZJe2Olav5PjNo273bXMF7yqpwJbg4E3n6OGGIzqACotTRox9DQqqSsFkyICXp9fOvvyO_bi2-7cIUe</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1751489499</pqid></control><display><type>article</type><title>Influence of phenotype conversion of epicardial adipocytes on the coronary atherosclerosis and its potential molecular mechanism</title><source>PubMed Central</source><creator>Wang, Jing ; Chen, Dong ; Cheng, Xun-Min ; Zhang, Qi-Gao ; Peng, Yong-Ping ; Wang, Li-Jun ; He, Song-Qing ; Gong, Jian-Bin</creator><creatorcontrib>Wang, Jing ; Chen, Dong ; Cheng, Xun-Min ; Zhang, Qi-Gao ; Peng, Yong-Ping ; Wang, Li-Jun ; He, Song-Qing ; Gong, Jian-Bin</creatorcontrib><description><![CDATA[To investigate the phenotype conversion of epicardial adipocytes and its potential molecular mechanism during the occurrence and development of coronary atherosclerosis. A total of 30 health male New Zealand white rabbits were used. In experiment group (n=15), rabbits were fed with high fat food to establish atherosclerosis animal model; rabbits in control group (n=15) were fed with normal food. At week 0, UCP-1 and PPARγ mRNA expressions in EAT and sBAT were significantly higher than in eWAT, and leptin mRNA expression lower than (P<0.05). In experiment group, the mRNA expressions of UCP-1 and PPARγ reduced gradually, but leptin mRNA increased progressively in EAT (P<0.05). UCP-1 expression reduced gradually, the newly generated blood vessels reduced significantly, but leptin and RAM11 increased gradually (P<0.05). The adipocyte volume in EAT increased gradually, but the adipocyte number reduced progressively (P<0.05). The number of mitochondria with multiple crests reduced gradually in EAT; IL-6 reduced the mRNA expressions of UCP-1 and PPARγ in adipocytes of BAT in a dose dependent manner, but it increased the mRNA expressions of leptin and STAT3 (P<0.05). In the presence of IL-6, JSI-124 increased the mRNA expressions of UCP-1 and PPAR-γ in adipocytes of BAT in a dose dependent manner, but it reduced the mRNA expressions of leptin and STAT3 (P<0.05). During the progression of atherosclerosis, there is a phenotype conversion of EAT from BAT to WAT, which further promotes the focal occurrence and development of atherosclerosis; IL-6 may activate JAK-STAT3 pathway to induce this conversion.]]></description><identifier>ISSN: 1943-8141</identifier><identifier>EISSN: 1943-8141</identifier><identifier>PMID: 26692919</identifier><language>eng</language><publisher>United States: e-Century Publishing Corporation</publisher><subject>Original</subject><ispartof>American journal of translational research, 2015-01, Vol.7 (10), p.1712-1723</ispartof><rights>AJTR Copyright © 2015 2015</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656752/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656752/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26692919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Chen, Dong</creatorcontrib><creatorcontrib>Cheng, Xun-Min</creatorcontrib><creatorcontrib>Zhang, Qi-Gao</creatorcontrib><creatorcontrib>Peng, Yong-Ping</creatorcontrib><creatorcontrib>Wang, Li-Jun</creatorcontrib><creatorcontrib>He, Song-Qing</creatorcontrib><creatorcontrib>Gong, Jian-Bin</creatorcontrib><title>Influence of phenotype conversion of epicardial adipocytes on the coronary atherosclerosis and its potential molecular mechanism</title><title>American journal of translational research</title><addtitle>Am J Transl Res</addtitle><description><![CDATA[To investigate the phenotype conversion of epicardial adipocytes and its potential molecular mechanism during the occurrence and development of coronary atherosclerosis. A total of 30 health male New Zealand white rabbits were used. In experiment group (n=15), rabbits were fed with high fat food to establish atherosclerosis animal model; rabbits in control group (n=15) were fed with normal food. At week 0, UCP-1 and PPARγ mRNA expressions in EAT and sBAT were significantly higher than in eWAT, and leptin mRNA expression lower than (P<0.05). In experiment group, the mRNA expressions of UCP-1 and PPARγ reduced gradually, but leptin mRNA increased progressively in EAT (P<0.05). UCP-1 expression reduced gradually, the newly generated blood vessels reduced significantly, but leptin and RAM11 increased gradually (P<0.05). The adipocyte volume in EAT increased gradually, but the adipocyte number reduced progressively (P<0.05). The number of mitochondria with multiple crests reduced gradually in EAT; IL-6 reduced the mRNA expressions of UCP-1 and PPARγ in adipocytes of BAT in a dose dependent manner, but it increased the mRNA expressions of leptin and STAT3 (P<0.05). In the presence of IL-6, JSI-124 increased the mRNA expressions of UCP-1 and PPAR-γ in adipocytes of BAT in a dose dependent manner, but it reduced the mRNA expressions of leptin and STAT3 (P<0.05). During the progression of atherosclerosis, there is a phenotype conversion of EAT from BAT to WAT, which further promotes the focal occurrence and development of atherosclerosis; IL-6 may activate JAK-STAT3 pathway to induce this conversion.]]></description><subject>Original</subject><issn>1943-8141</issn><issn>1943-8141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNpVUE1LxDAQLaK46-pfkBy9FJo2TZuLIIsfC4IXPZd0OnUjaRKTdGFv_nRbXGWdw3y-efOYk2RJBSvSmjJ6epQvkosQPrKMl4Ln58ki51zkgopl8rUxvR7RABLbE7dFY-PeIQFrduiDsmbuo1MgfaekJrJTzsI-YiDTLG5nqLdG-j2RU-VtAD17FYg0HVExEGcjmjgvD1YjjFp6MiBspVFhuEzOeqkDXh3iKnl7uH9dP6XPL4-b9d1z6iaxMW2BipoLgYBZ1ldssr4ARkvASmalANp2KCrgkNVYM2irDAALxgDrvJB5sUpuf3jd2A7YwaTIS904r4ZJe2Olav5PjNo273bXMF7yqpwJbg4E3n6OGGIzqACotTRox9DQqqSsFkyICXp9fOvvyO_bi2-7cIUe</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Wang, Jing</creator><creator>Chen, Dong</creator><creator>Cheng, Xun-Min</creator><creator>Zhang, Qi-Gao</creator><creator>Peng, Yong-Ping</creator><creator>Wang, Li-Jun</creator><creator>He, Song-Qing</creator><creator>Gong, Jian-Bin</creator><general>e-Century Publishing Corporation</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Influence of phenotype conversion of epicardial adipocytes on the coronary atherosclerosis and its potential molecular mechanism</title><author>Wang, Jing ; Chen, Dong ; Cheng, Xun-Min ; Zhang, Qi-Gao ; Peng, Yong-Ping ; Wang, Li-Jun ; He, Song-Qing ; Gong, Jian-Bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-bc198699ece00f74444f3c415ce7a059c1bde97c6c08e84cb70cce344ce823a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Chen, Dong</creatorcontrib><creatorcontrib>Cheng, Xun-Min</creatorcontrib><creatorcontrib>Zhang, Qi-Gao</creatorcontrib><creatorcontrib>Peng, Yong-Ping</creatorcontrib><creatorcontrib>Wang, Li-Jun</creatorcontrib><creatorcontrib>He, Song-Qing</creatorcontrib><creatorcontrib>Gong, Jian-Bin</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of translational research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jing</au><au>Chen, Dong</au><au>Cheng, Xun-Min</au><au>Zhang, Qi-Gao</au><au>Peng, Yong-Ping</au><au>Wang, Li-Jun</au><au>He, Song-Qing</au><au>Gong, Jian-Bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of phenotype conversion of epicardial adipocytes on the coronary atherosclerosis and its potential molecular mechanism</atitle><jtitle>American journal of translational research</jtitle><addtitle>Am J Transl Res</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>7</volume><issue>10</issue><spage>1712</spage><epage>1723</epage><pages>1712-1723</pages><issn>1943-8141</issn><eissn>1943-8141</eissn><abstract><![CDATA[To investigate the phenotype conversion of epicardial adipocytes and its potential molecular mechanism during the occurrence and development of coronary atherosclerosis. A total of 30 health male New Zealand white rabbits were used. In experiment group (n=15), rabbits were fed with high fat food to establish atherosclerosis animal model; rabbits in control group (n=15) were fed with normal food. At week 0, UCP-1 and PPARγ mRNA expressions in EAT and sBAT were significantly higher than in eWAT, and leptin mRNA expression lower than (P<0.05). In experiment group, the mRNA expressions of UCP-1 and PPARγ reduced gradually, but leptin mRNA increased progressively in EAT (P<0.05). UCP-1 expression reduced gradually, the newly generated blood vessels reduced significantly, but leptin and RAM11 increased gradually (P<0.05). The adipocyte volume in EAT increased gradually, but the adipocyte number reduced progressively (P<0.05). The number of mitochondria with multiple crests reduced gradually in EAT; IL-6 reduced the mRNA expressions of UCP-1 and PPARγ in adipocytes of BAT in a dose dependent manner, but it increased the mRNA expressions of leptin and STAT3 (P<0.05). In the presence of IL-6, JSI-124 increased the mRNA expressions of UCP-1 and PPAR-γ in adipocytes of BAT in a dose dependent manner, but it reduced the mRNA expressions of leptin and STAT3 (P<0.05). During the progression of atherosclerosis, there is a phenotype conversion of EAT from BAT to WAT, which further promotes the focal occurrence and development of atherosclerosis; IL-6 may activate JAK-STAT3 pathway to induce this conversion.]]></abstract><cop>United States</cop><pub>e-Century Publishing Corporation</pub><pmid>26692919</pmid><tpages>12</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1943-8141
ispartof American journal of translational research, 2015-01, Vol.7 (10), p.1712-1723
issn 1943-8141
1943-8141
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4656752
source PubMed Central
subjects Original
title Influence of phenotype conversion of epicardial adipocytes on the coronary atherosclerosis and its potential molecular mechanism
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T11%3A36%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20phenotype%20conversion%20of%20epicardial%20adipocytes%20on%20the%20coronary%20atherosclerosis%20and%20its%20potential%20molecular%20mechanism&rft.jtitle=American%20journal%20of%20translational%20research&rft.au=Wang,%20Jing&rft.date=2015-01-01&rft.volume=7&rft.issue=10&rft.spage=1712&rft.epage=1723&rft.pages=1712-1723&rft.issn=1943-8141&rft.eissn=1943-8141&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1751489499%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p266t-bc198699ece00f74444f3c415ce7a059c1bde97c6c08e84cb70cce344ce823a23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1751489499&rft_id=info:pmid/26692919&rfr_iscdi=true