High-throughput bacterial functional genomics in the sequencing era

Highlights • High-throughput phenotyping accelerates understanding of gene function and network. • Tn-seq is enabling functional genomics in a diverse set of bacteria. • Whole genome sequencing is accelerating forward genetic screens. • New approaches are expanding the types of phenotypes assayed on...

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Bibliographic Details
Published in:Current opinion in microbiology 2015-10, Vol.27, p.86-95
Main Authors: Gray, Andrew N, Koo, Byoung-Mo, Shiver, Anthony L, Peters, Jason M, Osadnik, Hendrik, Gross, Carol A
Format: Article
Language:English
Subjects:
Bacteria - genetics
DNA Barcoding, Taxonomic - methods
Genetic Variation
Genome, Bacterial
Genomics
High-Throughput Nucleotide Sequencing - methods
Pathology
Phenotype
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Summary:Highlights • High-throughput phenotyping accelerates understanding of gene function and network. • Tn-seq is enabling functional genomics in a diverse set of bacteria. • Whole genome sequencing is accelerating forward genetic screens. • New approaches are expanding the types of phenotypes assayed on a global scale.
ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2015.07.012