Hepatic manifestations of non-steroidal inflammatory bowel disease therapy

Inflammatory bowel disease(IBD) is composed of Crohn’s disease and ulcerative colitis and is manifested by both bowel-related and extraintestinal manifestations. Recently the number of therapeutic options available to treat IBD has dramatically increased, with each new medication having its own mech...

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Bibliographic Details
Published in:World journal of hepatology 2015-11, Vol.7 (27), p.2716-2728
Main Authors: Hirten, Robert, Sultan, Keith, Thomas, Ashby, Bernstein, David E
Format: Article
Language:English
Subjects:
drug
Hepatotoxicity
Adverse
induced
reactions
Drug
Review
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Summary:Inflammatory bowel disease(IBD) is composed of Crohn’s disease and ulcerative colitis and is manifested by both bowel-related and extraintestinal manifestations. Recently the number of therapeutic options available to treat IBD has dramatically increased, with each new medication having its own mechanism of action and side effect profile. A complete understanding of the hepatotoxicity of these medications is important in order to distinguish these complications from the hepatic manifestations of IBD. This review seeks to evaluate the hepatobiliary complications of non-steroid based IBD medications and aide providers in the recognition and management of these side-effects.
ISSN:1948-5182
1948-5182
DOI:10.4254/wjh.v7.i27.2716