Prevalence of chronic hepatitis B virus infection before and after implementation of a hepatitis B vaccination program among children in Nepal

Highlights • Between 2002 and 2004, Nepal implemented an infant routine hepatitis B vaccination. • A national serosurvey was conducted to assess HBsAg burden in children. • Among children born before vaccine introduction, 0.28% were positive for HBsAg. • Among children born after vaccine introductio...

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Bibliographic Details
Published in:Vaccine 2014-07, Vol.32 (34), p.4304-4309
Main Authors: Upreti, Shyam Raj, Gurung, Santosh, Patel, Minal, Dixit, Sameer M, Krause, L. Kendall, Shakya, Geeta, Wannemuehler, Kathleen, Rajbhandari, Rajesh, Bohara, Rajendra, Schluter, W. William
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antigens
Applied microbiology
Biological and medical sciences
Child
Child, Preschool
Children & youth
Consent
Cross-Sectional Studies
Female
Fundamental and applied biological sciences. Psychology
Hepatitis
Hepatitis B
Hepatitis B Surface Antigens - blood
Hepatitis B Vaccines - therapeutic use
Hepatitis B virus
Hepatitis B, Chronic - epidemiology
Hepatitis B, Chronic - prevention & control
Human viral diseases
Humans
Immunization
Immunization Programs
Infections
Infectious Disease Transmission, Vertical
Infectious diseases
Male
Medical sciences
Microbiology
Miscellaneous
Mothers
Nepal
Nepal - epidemiology
Population
Predictive Value of Tests
Prevalence
Rural areas
Sample size
Sensitivity and Specificity
Seroepidemiologic Studies
Seroprevalence
Vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Viral hepatitis
Virology
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Summary:Highlights • Between 2002 and 2004, Nepal implemented an infant routine hepatitis B vaccination. • A national serosurvey was conducted to assess HBsAg burden in children. • Among children born before vaccine introduction, 0.28% were positive for HBsAg. • Among children born after vaccine introduction, 0.13% were positive for HBsAg.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.06.027