Dermal Absorption of Finite doses of Volatile Compounds

Laplace domain solutions to a previously published finite dose skin diffusion model are presented. The purpose of the current analysis is to derive a simple algebraic expression quantifying the total mass that is systemically absorbed at infinite time after exposure, relative to the applied mass. Th...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2012-07, Vol.101 (7), p.2616-2619
Main Author: Frederick Frasch, H.
Format: Article
Language:English
Subjects:
absorption
Algorithms
Biological and medical sciences
Diffusion
General pharmacology
Humans
mathematical model
Medical sciences
Models, Biological
percutaneous
permeability
Pharmaceutical technology. Pharmaceutical industry
Pharmacokinetics
Pharmacology. Drug treatments
Risk assessment
skin
Skin - metabolism
Skin Absorption
solvent evaporation
Volatilization
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Summary:Laplace domain solutions to a previously published finite dose skin diffusion model are presented. The purpose of the current analysis is to derive a simple algebraic expression quantifying the total mass that is systemically absorbed at infinite time after exposure, relative to the applied mass. The resulting expression is a function of two dimensionless parameters: f, the fractional depth within the skin surface through which the permeant is initially deposited, and χ, the ratio of maximum evaporation flux to maximum dermal flux. The result may be useful for dermal risk assessment as well as in the evaluation of cosmetic and pharmaceutical product performance. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.23149