Progress in material design for biomedical applications

Biomaterials that interface with biological systems are used to deliver drugs safely and efficiently; to prevent, detect, and treat disease; to assist the body as it heals; and to engineer functional tissues outside of the body for organ replacement. The field has evolved beyond selecting materials...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2015-11, Vol.112 (47), p.14444-14451
Main Authors: Tibbitt, Mark W, Christopher B. Rodell, Jason A. Burdick, Kristi S. Anseth
Format: Article
Language:English
Subjects:
Biocompatible Materials
biocomplex
Biological Sciences
biomaterials
Biomedical materials
drugs
dynamics
feature control
Humans
Pathology
Physical Sciences
soft materials
SPECIAL FEATURE: PERSPECTIVE
The Engineering of Biology and Medicine PNAS 100th Anniversary Special Feature
Tissue Engineering
Tissues
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Summary:Biomaterials that interface with biological systems are used to deliver drugs safely and efficiently; to prevent, detect, and treat disease; to assist the body as it heals; and to engineer functional tissues outside of the body for organ replacement. The field has evolved beyond selecting materials that were originally designed for other applications with a primary focus on properties that enabled restoration of function and mitigation of acute pathology. Biomaterials are now designed rationally with controlled structure and dynamic functionality to integrate with biological complexity and perform tailored, high-level functions in the body. The transition has been from permissive to promoting biomaterials that are no longer bioinert but bioactive. This perspective surveys recent developments in the field of polymeric and soft biomaterials with a specific emphasis on advances in nano- to macroscale control, static to dynamic functionality, and biocomplex materials.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1516247112