Effects and mechanism of Xin Mai Jia in a rabbit model of atherosclerosis

The aim of this study was to investigate the protective effects of Xin Mai Jia (XMJ) on atherosclerosis (AS) in rabbits and to explore the underlying mechanisms in order to provide experimental evidence for the clinical application of XMJ. An intraperitoneal injection of vitamin D3, combined with a...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2015-11, Vol.10 (5), p.1627-1634
Main Authors: ZHAO, FAN-RONG, LU, JUN-XIU, JIA, MEI, YIN, YA-LING, QI, HENG-TIAN, ZHU, MO-LI, MA, LI-JUAN, QIU, LE-LE, WAN, GUANG-MING, WAN, GUANG-RUI
Format: Article
Language:English
Subjects:
Atherosclerosis
Care and treatment
Carotid arteries
Cholesterol
Endothelium
hyperlipidemia
Laboratory animals
Lipids
Lipoproteins
Rabbits
Rodents
Smooth muscle
Veins & arteries
Xin Mai Jia
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Summary:The aim of this study was to investigate the protective effects of Xin Mai Jia (XMJ) on atherosclerosis (AS) in rabbits and to explore the underlying mechanisms in order to provide experimental evidence for the clinical application of XMJ. An intraperitoneal injection of vitamin D3, combined with a high-fat diet and sacculus injury, was utilized to establish the AS rabbit model. Following the oral administration of lovastatin, Zhibituo and different dosages of XMJ, respectively, blood was drawn from each rabbit for the detection of blood rheological indicators, such as serum lipids. The pathological changes in the right common carotid artery were observed. Vascular function experiments and the expression detection of common carotid artery-related proteins by immunohistochemistry were conducted. XMJ was observed to decrease the blood lipid levels of the AS rabbits; increase the concentration of high-density lipoprotein and apolipoprotein A; decrease blood viscosity, erythrocyte sedimentation rate and hematocrit; elevate the levels of endothelial nitric oxide synthase (eNOS) and Na+/H+ exchanger 1 in vascular tissues and decrease the levels of angiotensin II receptor, type 1 (AT-1) and endothelin-1 (ET-1). In conclusion, XMJ was shown to lower the blood lipid levels of the experimental AS rabbits, improve the abnormal changes in hemorheology, increase the eNOS content in the vascular tissue, decrease the AT-1 and ET-1 levels and increase the endothelium-dependent vasodilation reaction. XMJ therefore has an anti-AS effect.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2015.2774