Patterns of epidermal growth factor receptor mutation in non-small-cell lung cancers in the Gulf region

The aim of the present study was to determine the prevalence of epidermal growth factor receptor mutations (EGFRmut) in the Gulf region (GR) and its correlation with demographic and clinical characteristics. A multisite retrospective study was conducted, including institutions from Saudi Arabia, the...

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Bibliographic Details
Published in:Molecular and clinical oncology 2015-11, Vol.3 (6), p.1371-1374
Main Authors: JAZIEH, ABDUL RAHMAN, JAAFAR, HASAN, JALOUDI, MOHAMMED, MUSTAFA, RASHA SALEH, RASUL, KAKIL, ZEKRI, JAMAL, BAMEFLEH, HANAA, GASMELSEED, AHMED
Format: Article
Language:English
Subjects:
Analysis
Cancer therapies
Confidence intervals
Epidermal growth factor
epidermal growth factor receptor
Gender
Gene mutations
Genetic aspects
Gulf region
Health aspects
Histology
Lung cancer
Lung cancer, Non-small cell
Multivariate analysis
Mutation
non-small-cell lung cancer
Oncology
Patients
Regression analysis
Risk factors
Statistical analysis
Studies
Survival analysis
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Summary:The aim of the present study was to determine the prevalence of epidermal growth factor receptor mutations (EGFRmut) in the Gulf region (GR) and its correlation with demographic and clinical characteristics. A multisite retrospective study was conducted, including institutions from Saudi Arabia, the United Arab Emirates and Qatar. All consecutive patients with non-small-cell lung cancer tested for EGFRmut were eligible. Data collected included demographic information, disease characteristics and EGFR test results. Data on 230 patients were obtained. The median age of the patients was 61 years (range, 26-87 years); 169 patients (69.83%) were male and 204 (88.7%) were Arab. The histological subtype was adenocarcinoma in 191 (83.4%) and squamous cell carcinoma in 21 cases (9.17%). Overall, EGFRmut were detected in 66 patients (28.7%), with a prevalence of 32.46% in adenocarcinoma. No squamous cell carcinomas were found to harbor EGFRmut. The univariate and multivariate analyses revealed that female gender, non-smoking status and adenocarcinoma subtype were significant predictors for EGFRmut. There was no difference between Arabs and non-Arabs. In conclusion, to the best of our knowledge, this is the first multisite study to report the prevalence of EGFRmut in the GR population, which was found to be higher compared with that in Western, but lower compared with that in Far Eastern populations. Studies evaluating the efficacy of targeted therapy in this population are underway.
ISSN:2049-9450
2049-9469
DOI:10.3892/mco.2015.644