Extramedullary blast crisis as initial presentation in chronic myeloid leukemia with the e1a2 BCR-ABL1 transcript: A case report

A 23-year-old woman presented with enlarged right inguinal lymph nodes. The pathological examination of the nodes revealed infiltration by myeloid sarcoma. A bone marrow smear and biopsy revealed cytogenetic abnormalities, with 46,XX,t(9;22) and chronic myeloid leukemia (CML) was diagnosed. The e1a2...

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Bibliographic Details
Published in:Molecular and clinical oncology 2015-11, Vol.3 (6), p.1319-1322
Main Authors: AI, DI, LIU, WEI, LU, GARY, PATEL, KEYUR PRAVINCHANDRA, CHEN, ZI
Format: Article
Language:English
Subjects:
Blood
bone marrow transplant
Cancer
Care and treatment
Case reports
Case studies
Chemotherapy
Chronic myeloid leukemia
Cytogenetics
Diagnosis
e1a2 transcript
extramedullary blast crisis
Family medical history
Granulocytes
Health aspects
Hematology
Hematopoietic stem cells
Leukemia
Lymphatic system
Morphology
Oncology
Patients
Stem cell transplantation
targeted therapy
Transplantation
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Summary:A 23-year-old woman presented with enlarged right inguinal lymph nodes. The pathological examination of the nodes revealed infiltration by myeloid sarcoma. A bone marrow smear and biopsy revealed cytogenetic abnormalities, with 46,XX,t(9;22) and chronic myeloid leukemia (CML) was diagnosed. The e1a2 BCR-ABL1 fusion transcript was detected. The patient received imatinib-based combined chemotherapy, allogeneic hematopoietic stem cell transplantation, donor lymphocyte infusions and dasatinib treatment. The patient achieved complete response and has remained leukemia-free for >48 months. To the best of our knowledge, this is the first case report of CML with the e1a2 BCR-ABL1 transcript, with extramedullary blast crisis as the initial presentation. The aim of the present study was to discuss this special case with reference to the literature.
ISSN:2049-9450
2049-9469
DOI:10.3892/mco.2015.641