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Angiotensin II type-1 receptor blockers enhance the effects of bevacizumab-based chemotherapy in metastatic colorectal cancer patients
The local renin-angiotensin system promotes angiogenesis and vascular proliferation via expression of vascular endothelial growth factor or epidermal growth factor receptor. We hypothesized that angiotensin II type-1 receptor blockers (ARBs) in combination with bevacizumab (Bev) may improve clinical...
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Published in: | Molecular and clinical oncology 2015-11, Vol.3 (6), p.1295-1300 |
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description | The local renin-angiotensin system promotes angiogenesis and vascular proliferation via expression of vascular endothelial growth factor or epidermal growth factor receptor. We hypothesized that angiotensin II type-1 receptor blockers (ARBs) in combination with bevacizumab (Bev) may improve clinical outcomes in patients with metastatic colorectal cancer (mCRC). A total of 181 patients with histopathologically confirmed mCRC treated with first-line oxaliplatin-based chemotherapy in combination with Bev were enrolled between June, 2007 and September, 2010. The patients were divided into two groups based on the presence or absence of treatment with ARBs prior to the initiation of second-line chemotherapy. Kaplan-Meier analysis and Cox proportional hazard modeling were used in the statistical analysis. The median progression-free survival (PFS) in patients undergoing second-line chemotherapy in combination with Bev and ARBs (n=56) vs. those treated in the absence of ARBs (n=33) was 8.3 vs. 5.7 months, respectively [hazard ratio (HR)=0.57, 95% confidence interval (CI): 0.35-0.94, P=0.028]. The median overall survival (OS) was 26.5 vs. 15.2 months, respectively (HR=0.47, 95% CI: 0.25-0.88, P=0.019). In the multivariate analysis, the use of ARBs was independently associated with prolongation of OS and PFS. In conclusion, the use of ARBs prolonged survival in mCRC patients. |
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We hypothesized that angiotensin II type-1 receptor blockers (ARBs) in combination with bevacizumab (Bev) may improve clinical outcomes in patients with metastatic colorectal cancer (mCRC). A total of 181 patients with histopathologically confirmed mCRC treated with first-line oxaliplatin-based chemotherapy in combination with Bev were enrolled between June, 2007 and September, 2010. The patients were divided into two groups based on the presence or absence of treatment with ARBs prior to the initiation of second-line chemotherapy. Kaplan-Meier analysis and Cox proportional hazard modeling were used in the statistical analysis. The median progression-free survival (PFS) in patients undergoing second-line chemotherapy in combination with Bev and ARBs (n=56) vs. those treated in the absence of ARBs (n=33) was 8.3 vs. 5.7 months, respectively [hazard ratio (HR)=0.57, 95% confidence interval (CI): 0.35-0.94, P=0.028]. The median overall survival (OS) was 26.5 vs. 15.2 months, respectively (HR=0.47, 95% CI: 0.25-0.88, P=0.019). In the multivariate analysis, the use of ARBs was independently associated with prolongation of OS and PFS. In conclusion, the use of ARBs prolonged survival in mCRC patients.</description><identifier>ISSN: 2049-9450</identifier><identifier>EISSN: 2049-9469</identifier><identifier>DOI: 10.3892/mco.2015.630</identifier><identifier>PMID: 26807236</identifier><language>eng</language><publisher>England: D.A. Spandidos</publisher><subject>Age ; Angiogenesis ; Angiotensin II receptor blockers ; angiotensin II type-1 receptor blockers ; bevacizumab ; Chemotherapy ; Clinical outcomes ; Colorectal cancer ; Confidence intervals ; Disease control ; Drug therapy ; Gender ; Health aspects ; Hypertension ; Immunotherapy ; Liver ; Lymphatic system ; Medical prognosis ; Metastasis ; Monoclonal antibodies ; Multivariate analysis ; Oncology ; Pancreatic cancer ; Patients ; Rodents ; Targeted cancer therapy ; Tumors ; Vascular endothelial growth factor</subject><ispartof>Molecular and clinical oncology, 2015-11, Vol.3 (6), p.1295-1300</ispartof><rights>Copyright © 2015, Spandidos Publications</rights><rights>COPYRIGHT 2015 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2015</rights><rights>Copyright © 2015, Spandidos Publications 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-d5d7a2f5ee1b746727579aba14653e32110ae276f51b622c8a358c985b4809bf3</citedby><cites>FETCH-LOGICAL-c504t-d5d7a2f5ee1b746727579aba14653e32110ae276f51b622c8a358c985b4809bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665652/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665652/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26807236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OSUMI, HIROKI</creatorcontrib><creatorcontrib>MATSUSAKA, SATOSHI</creatorcontrib><creatorcontrib>WAKATSUKI, TAKERU</creatorcontrib><creatorcontrib>SUENAGA, MITSUKUNI</creatorcontrib><creatorcontrib>SHINOZAKI, EIIJ</creatorcontrib><creatorcontrib>MIZUNUMA, NOBUYUKI</creatorcontrib><title>Angiotensin II type-1 receptor blockers enhance the effects of bevacizumab-based chemotherapy in metastatic colorectal cancer patients</title><title>Molecular and clinical oncology</title><addtitle>Mol Clin Oncol</addtitle><description>The local renin-angiotensin system promotes angiogenesis and vascular proliferation via expression of vascular endothelial growth factor or epidermal growth factor receptor. We hypothesized that angiotensin II type-1 receptor blockers (ARBs) in combination with bevacizumab (Bev) may improve clinical outcomes in patients with metastatic colorectal cancer (mCRC). A total of 181 patients with histopathologically confirmed mCRC treated with first-line oxaliplatin-based chemotherapy in combination with Bev were enrolled between June, 2007 and September, 2010. The patients were divided into two groups based on the presence or absence of treatment with ARBs prior to the initiation of second-line chemotherapy. Kaplan-Meier analysis and Cox proportional hazard modeling were used in the statistical analysis. The median progression-free survival (PFS) in patients undergoing second-line chemotherapy in combination with Bev and ARBs (n=56) vs. those treated in the absence of ARBs (n=33) was 8.3 vs. 5.7 months, respectively [hazard ratio (HR)=0.57, 95% confidence interval (CI): 0.35-0.94, P=0.028]. The median overall survival (OS) was 26.5 vs. 15.2 months, respectively (HR=0.47, 95% CI: 0.25-0.88, P=0.019). In the multivariate analysis, the use of ARBs was independently associated with prolongation of OS and PFS. In conclusion, the use of ARBs prolonged survival in mCRC patients.</description><subject>Age</subject><subject>Angiogenesis</subject><subject>Angiotensin II receptor blockers</subject><subject>angiotensin II type-1 receptor blockers</subject><subject>bevacizumab</subject><subject>Chemotherapy</subject><subject>Clinical outcomes</subject><subject>Colorectal cancer</subject><subject>Confidence intervals</subject><subject>Disease control</subject><subject>Drug therapy</subject><subject>Gender</subject><subject>Health aspects</subject><subject>Hypertension</subject><subject>Immunotherapy</subject><subject>Liver</subject><subject>Lymphatic system</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Monoclonal antibodies</subject><subject>Multivariate analysis</subject><subject>Oncology</subject><subject>Pancreatic cancer</subject><subject>Patients</subject><subject>Rodents</subject><subject>Targeted cancer therapy</subject><subject>Tumors</subject><subject>Vascular endothelial growth factor</subject><issn>2049-9450</issn><issn>2049-9469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNptkkGP1CAYhhujcTfr3jwbEj14sCPQAuViMpm4OsmaveiZUPp1hrWFCnST8Qf4u5dm1tE1wgECD8-Xj7xF8ZLgVdVI-n40fkUxYSte4SfFOcW1LGXN5dPTnuGz4jLGW5yHFJgy-bw4o7zBglb8vPi1djvrE7hoHdpuUTpMUBIUwMCUfEDt4M13CBGB22tnAKU9IOh7MCki36MW7rSxP-dRt2WrI3TI7GH0mQp6OqAsHSHpmHSyBhk_-GxOekBmkQU05XNwKb4onvV6iHD5sF4U364-ft18Lq9vPm036-vSMFynsmOd0LRnAKQVNRdUMCF1q0nNWQUVJQRroIL3jLScUtPoijVGNqytGyzbvrooPhy909yO0JlcO-hBTcGOOhyU11Y9vnF2r3b-TtWcM85oFrx9EAT_Y4aY1GijgWHQDvwcFWko57XAWGT09T_orZ-Dy-0pIitaM8oE-0Pt9ADKut7numaRqnVdSdJwIXCmVv-h8uxgtMY76G0-f_Tg3fGBCT7GAP2pR4LVEh2Vo6OW6KgcnYy_-vtfTvDvoGTgzRGIk3ad7Xw8MV82NyXOc_HcA502y7E</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>OSUMI, HIROKI</creator><creator>MATSUSAKA, SATOSHI</creator><creator>WAKATSUKI, TAKERU</creator><creator>SUENAGA, MITSUKUNI</creator><creator>SHINOZAKI, EIIJ</creator><creator>MIZUNUMA, NOBUYUKI</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151101</creationdate><title>Angiotensin II type-1 receptor blockers enhance the effects of bevacizumab-based chemotherapy in metastatic colorectal cancer patients</title><author>OSUMI, HIROKI ; MATSUSAKA, SATOSHI ; WAKATSUKI, TAKERU ; SUENAGA, MITSUKUNI ; SHINOZAKI, EIIJ ; MIZUNUMA, NOBUYUKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-d5d7a2f5ee1b746727579aba14653e32110ae276f51b622c8a358c985b4809bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age</topic><topic>Angiogenesis</topic><topic>Angiotensin II receptor blockers</topic><topic>angiotensin II type-1 receptor blockers</topic><topic>bevacizumab</topic><topic>Chemotherapy</topic><topic>Clinical outcomes</topic><topic>Colorectal cancer</topic><topic>Confidence intervals</topic><topic>Disease control</topic><topic>Drug therapy</topic><topic>Gender</topic><topic>Health aspects</topic><topic>Hypertension</topic><topic>Immunotherapy</topic><topic>Liver</topic><topic>Lymphatic system</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Monoclonal antibodies</topic><topic>Multivariate analysis</topic><topic>Oncology</topic><topic>Pancreatic cancer</topic><topic>Patients</topic><topic>Rodents</topic><topic>Targeted cancer therapy</topic><topic>Tumors</topic><topic>Vascular endothelial growth factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OSUMI, HIROKI</creatorcontrib><creatorcontrib>MATSUSAKA, SATOSHI</creatorcontrib><creatorcontrib>WAKATSUKI, TAKERU</creatorcontrib><creatorcontrib>SUENAGA, MITSUKUNI</creatorcontrib><creatorcontrib>SHINOZAKI, EIIJ</creatorcontrib><creatorcontrib>MIZUNUMA, NOBUYUKI</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OSUMI, HIROKI</au><au>MATSUSAKA, SATOSHI</au><au>WAKATSUKI, TAKERU</au><au>SUENAGA, MITSUKUNI</au><au>SHINOZAKI, EIIJ</au><au>MIZUNUMA, NOBUYUKI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensin II type-1 receptor blockers enhance the effects of bevacizumab-based chemotherapy in metastatic colorectal cancer patients</atitle><jtitle>Molecular and clinical oncology</jtitle><addtitle>Mol Clin Oncol</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>3</volume><issue>6</issue><spage>1295</spage><epage>1300</epage><pages>1295-1300</pages><issn>2049-9450</issn><eissn>2049-9469</eissn><abstract>The local renin-angiotensin system promotes angiogenesis and vascular proliferation via expression of vascular endothelial growth factor or epidermal growth factor receptor. We hypothesized that angiotensin II type-1 receptor blockers (ARBs) in combination with bevacizumab (Bev) may improve clinical outcomes in patients with metastatic colorectal cancer (mCRC). A total of 181 patients with histopathologically confirmed mCRC treated with first-line oxaliplatin-based chemotherapy in combination with Bev were enrolled between June, 2007 and September, 2010. The patients were divided into two groups based on the presence or absence of treatment with ARBs prior to the initiation of second-line chemotherapy. Kaplan-Meier analysis and Cox proportional hazard modeling were used in the statistical analysis. The median progression-free survival (PFS) in patients undergoing second-line chemotherapy in combination with Bev and ARBs (n=56) vs. those treated in the absence of ARBs (n=33) was 8.3 vs. 5.7 months, respectively [hazard ratio (HR)=0.57, 95% confidence interval (CI): 0.35-0.94, P=0.028]. The median overall survival (OS) was 26.5 vs. 15.2 months, respectively (HR=0.47, 95% CI: 0.25-0.88, P=0.019). In the multivariate analysis, the use of ARBs was independently associated with prolongation of OS and PFS. In conclusion, the use of ARBs prolonged survival in mCRC patients.</abstract><cop>England</cop><pub>D.A. Spandidos</pub><pmid>26807236</pmid><doi>10.3892/mco.2015.630</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Age Angiogenesis Angiotensin II receptor blockers angiotensin II type-1 receptor blockers bevacizumab Chemotherapy Clinical outcomes Colorectal cancer Confidence intervals Disease control Drug therapy Gender Health aspects Hypertension Immunotherapy Liver Lymphatic system Medical prognosis Metastasis Monoclonal antibodies Multivariate analysis Oncology Pancreatic cancer Patients Rodents Targeted cancer therapy Tumors Vascular endothelial growth factor |
title | Angiotensin II type-1 receptor blockers enhance the effects of bevacizumab-based chemotherapy in metastatic colorectal cancer patients |
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