Isolated lymphoma of the optic nerve, chiasm and tract: A case report

The current study reports the case of a 68-year-old, previously healthy female who presented with progressive visual impairment leading to blindness bilaterally. Brain imaging features were suggestive of malignant glioma of the anterior visual pathway. Postoperative examination indicated a diagnosis...

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Bibliographic Details
Published in:Oncology letters 2015-11, Vol.10 (5), p.3013-3017
Main Authors: ZHU, YUE-LI, SONG, XIU-FENG, WANG, BIN
Format: Article
Language:English
Subjects:
Antigens
Brain cancer
Cardiovascular disease
Care and treatment
Case reports
Case studies
Chemotherapy
computed tomography
Diagnosis
Family medical history
Lymphoma
Lymphomas
magnetic resonance imaging
Medical imaging
Medical prognosis
Metastasis
NMR
Nuclear magnetic resonance
Optic nerve
Pathology
Patients
Pediatrics
Population
Radiation therapy
Surgery
Tumors
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Summary:The current study reports the case of a 68-year-old, previously healthy female who presented with progressive visual impairment leading to blindness bilaterally. Brain imaging features were suggestive of malignant glioma of the anterior visual pathway. Postoperative examination indicated a diagnosis of diffuse malignant lymphoma type B. As no evidence of extracranial lymphoma was observed, the final diagnosis was primary central nervous system lymphoma (PCNSL). Following treatment with surgery and radiotherapy, the patient's symptoms went into remission. At a follow-up examination 12 months after diagnosis, the patient demonstrated no evidence of recurrence. To the best of our knowledge, PCNSL isolated to the optic chiasm has been reported only three times in immunocompetent patients. Therefore, the present case of the lymphoma involving the optic nerve, optic chiasm and optic tract in an immunocompetent patient is unusual. The present case emphasizes the importance of considering the diagnosis of lymphoma in this setting.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2015.3675