Upregulation of circulating cytokeratin 20, urokinase plasminogen activator and C-reactive protein is associated with poor prognosis in gastric cancer

Gastric cancer is one of the most common types of cancer, with a high mortality rate. The aim of this study was to investigate the role of several key molecules, including cytokeratin (CK) 19 and CK20, urokinase plasminogen activator (uPA), C-reactive protein (CRP) and matrix metalloproteinase (MMP)...

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Bibliographic Details
Published in:Molecular and clinical oncology 2015-11, Vol.3 (6), p.1213-1220
Main Authors: TANG, ZHONGZHU, SHENG, HUAYING, ZHENG, XIAO, YING, LISHA, WU, LIE, LIU, DONG, LIU, GUAN
Format: Article
Language:English
Subjects:
Age
Analysis
C-reactive protein
Cancer therapies
Cell cycle
Chemotherapy
cytokeratin 19/20
Gastric cancer
gastric carcinoma
Gender
Health aspects
Keratin
Medical prognosis
Metastasis
Oncology
Physiological aspects
Prognosis
Proteins
Stomach cancer
Thrombolytic drugs
Tumors
urokinase plasminogen activator
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Summary:Gastric cancer is one of the most common types of cancer, with a high mortality rate. The aim of this study was to investigate the role of several key molecules, including cytokeratin (CK) 19 and CK20, urokinase plasminogen activator (uPA), C-reactive protein (CRP) and matrix metalloproteinase (MMP)-9, which are involved in cancer invasion and metastasis, in order to determine whether they may be considered as novel prognostic factors for gastric cancer. Peripheral blood was collected from 165 patients with gastric adenocarcinoma who underwent curative surgical resection at Zhejiang Cancer Hospital (Hangzhou, China) between 2010 and 2011. The mRNA levels of CK19, CK20, uPA and MMP-9 were detected by reverse transcription-quantitative polymerase chain reaction. The protein expression of CRP was measured by immunoturbidimetry. The Students t-test was used in the univariate analyses and the Kaplan-Meier method was used to analyze the survival curves. The relative mRNA expression of CK19 and MMP-9 was not found to be significantly associated with gender, age or cancer stage, whereas that of CK20 and uPA was associated with gastric cancer stage: The low-expression group was associated with early-stage and the high-expression group with more advanced-stage disease (P
ISSN:2049-9450
2049-9469
DOI:10.3892/mco.2015.624