Genipin-Crosslinked Gelatin-Based Emulgels: an Insight into the Thermal, Mechanical, and Electrical Studies

• Published in: AAPS PharmSciTech 2015-12, Vol.16 (6), p.1254-1262
• Main Authors: Mallick, Sarada P., Sagiri, Sai S., Singh, Vinay K., Behera, Beauty, Thirugnanam, A., Pradhan, Dillip K., Bhattacharya, Mrinal K., Pal, Kunal
• Format: Article
• Language: English
• Subjects: Anti-Infective Agents - administration & dosage; Anti-Infective Agents - chemistry; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Chemistry, Pharmaceutical - methods; Ciprofloxacin - administration & dosage; Ciprofloxacin - chemistry; Drug Liberation; Electricity; Emulsions - administration & dosage; Emulsions - chemistry; Gelatin - administration & dosage; Gelatin - chemistry; Gels - administration & dosage; Gels - chemistry; Iridoids - administration & dosage; Iridoids - chemistry; Pharmacology/Toxicology; Pharmacy; Research Article
• ISSN: 1530-9932; 1530-9932
• DOI: 10.1208/s12249-014-0260-2

The present study discusses about the preparation and characterization (thermal, mechanical, and electrical) of the genipin-crosslinked gelatin emulgels. Emulgels have gained importance in recent years due to their improved stability than emulsions and ability to control the drug release. Mustard oil was used as the representative oil. A decrease in the enthalpy and entropy of the formulations was observed with the increase in the oil fraction. The mechanical studies suggested formation of softer emulgels as the oil fraction was increased. As the proportion of the oil fraction was increased in the emulgels, there was a corresponding increase in the impedance. The drug release properties from the emulgels were also studied. Ciprofloxacin was used as the model antimicrobial drug. The drug release was higher from the emulgels whose electrical conductivity was higher.