Disruption of 5-HT1A function in adolescence but not early adulthood leads to sustained increases of anxiety

Highlights • Temporary loss of 5-HT1A function after P35, but not after P50, results in increased anxiety-like behaviors in adulthood. • Adolescent blockade of 5-HT1A receptors results in long-term changes in serotonin levels. • Adult anxiety phenotype correlates with increased serotonin levels in s...

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Bibliographic Details
Published in:Neuroscience 2016-05, Vol.321, p.210-221
Main Authors: Garcia-Garcia, A.L, Meng, Q, Richardson-Jones, J, Dranovsky, A, Leonardo, E.D
Format: Article
Language:English
Subjects:
5-HT1A
8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology
adolescence
Age Factors
Animals
anxiety
Anxiety - metabolism
Anxiety - psychology
Conflict (Psychology)
Corticosterone - blood
depression
development
Male
Mice, Knockout
Neurology
Piperazines - pharmacology
Pyridines - pharmacology
Receptor, Serotonin, 5-HT1A - genetics
Receptor, Serotonin, 5-HT1A - physiology
serotonin
Serotonin - physiology
Serotonin 5-HT1 Receptor Agonists - pharmacology
Serotonin 5-HT1 Receptor Antagonists - pharmacology
Signal Transduction
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Summary:Highlights • Temporary loss of 5-HT1A function after P35, but not after P50, results in increased anxiety-like behaviors in adulthood. • Adolescent blockade of 5-HT1A receptors results in long-term changes in serotonin levels. • Adult anxiety phenotype correlates with increased serotonin levels in select brain regions. • Brief interventions in the 5-HT system during adolescence lead to profound and enduring changes in behavior.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.05.076