Genetic diversity and antimicrobial susceptibility of Nocardia species among patients with nocardiosis

The aim of this multicenter study was to determine the genetic diversity and antibiotic susceptibility of clinically isolated Nocardia species. One hundred twenty-seven patients with nocardiosis were randomly selected from 5 provinces of Iran. Molecular diagnosis of Nocardia species was performed us...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2015-12, Vol.5 (1), p.17862-17862, Article 17862
Main Authors: Hashemi-Shahraki, Abodolrazagh, Heidarieh, Parvin, Bostanabad, Saeed Zaker, Hashemzadeh, Mohamad, Feizabadi, Mohamad Mehdi, Schraufnagel, Dean, Mirsaeidi, Mehdi
Format: Article
Language:English
Subjects:
13
45
45/23
631/326/325/1506
692/699/255/1318
Anti-Infective Agents - pharmacology
Base Sequence
Demography
DNA topoisomerase
Female
Genetic diversity
Genetic Variation
Geography
Humanities and Social Sciences
Humans
Imipenem
Linezolid
Male
Microbial Sensitivity Tests
Middle Aged
multidisciplinary
Nocardia - drug effects
Nocardia - genetics
Nocardia - isolation & purification
Nocardia Infections - microbiology
Nocardiosis
Nucleotide sequence
Phylogeny
RNA, Ribosomal, 16S - genetics
rRNA 16S
Science
Species
Species Specificity
Sulfamethoxazole
Trimethoprim
Trimethoprim-sulfamethoxazole
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c438t-2979ebc3faa2231a8a55e22a76fd9ab735aea5ae129ccf8ebf2a1ccd29d112803
cites cdi_FETCH-LOGICAL-c438t-2979ebc3faa2231a8a55e22a76fd9ab735aea5ae129ccf8ebf2a1ccd29d112803
container_end_page 17862
container_issue 1
container_start_page 17862
container_title Scientific reports
container_volume 5
creator Hashemi-Shahraki, Abodolrazagh
Heidarieh, Parvin
Bostanabad, Saeed Zaker
Hashemzadeh, Mohamad
Feizabadi, Mohamad Mehdi
Schraufnagel, Dean
Mirsaeidi, Mehdi
description The aim of this multicenter study was to determine the genetic diversity and antibiotic susceptibility of clinically isolated Nocardia species. One hundred twenty-seven patients with nocardiosis were randomly selected from 5 provinces of Iran. Molecular diagnosis of Nocardia species was performed using multilocus sequence analysis of gyrase B of the β subunit of DNA topoisomerase ( gyrB ) and 16S rRNA and subunit A of SecA preproteintranslocase ( secA1 ). Antimicrobial susceptibility testing was performed following the Clinical and Laboratory Standards Institute recommendations. Thirty-five N. cyriacigeorgica , 30 N. asteroides , 26 N. farcinica , 12 N. otitidiscaviarum, and 10 N. abscessus cultures were studied. All isolates were susceptible to linezolid. All isolates of N. cyriacigeorgica , N. asteroides, N. abscessus and N. otitidiscaviarum were susceptible to trimethoprim-sulfamethoxazole, while 8% of N. farcinica isolates were resistant to this drug. All N. otitidiscaviarum isolates were highly resistant to imipenem, but N. cyriacigeorgica , N. asteroides, N. farcinica and N. abscessus were only moderate resistant. The susceptibility patterns vary with different species of Nocardia . Resistance to trimethoprim-sulfamethoxazole in Iran is low and this drug should be first line therapy, unless drug susceptibility testing shows resistance. Linezolid also covers Nocardia well and could be a second line agent.
doi_str_mv 10.1038/srep17862
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4671095</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1746870701</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-2979ebc3faa2231a8a55e22a76fd9ab735aea5ae129ccf8ebf2a1ccd29d112803</originalsourceid><addsrcrecordid>eNplkV9rFTEQxYMottQ--AUk4IsWrmayf5J9EaTYKhR90ecwm83eTtlN1iRb6bc3l1svVw0MCcyPkzNzGHsJ4h2ISr9P0S2gdCufsFMp6mYjKymfHr1P2HlKd6KcRnY1dM_ZiWzbSisFp2y8dt5lsnygexcT5QeOfiiVaSYbQ0848bQm65ZMPU07IIz8a7AYB0KeFmfJJY5z8Fu-YCbnc-K_KN9yv4dCovSCPRtxSu788T5jP64-fb_8vLn5dv3l8uPNxtaVzhvZqc71thoRpawANTaNkxJVOw4d9qpq0GEpkJ21o3b9KBGsHWQ3AEgtqjP2Ya-7rP3sBlvMRJzMEmnG-GACkvm74-nWbMO9qVsFomuKwJtHgRh-ri5lM1MZfprQu7AmA6putRJKQEFf_4PehTX6Mp4BLcqGW4Cd4Ns9VZaZSlbjwQwIswvQHAIs7Ktj9wfyT1wFuNgDqbT81sWjL_9T-w2T-6gt</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1806636115</pqid></control><display><type>article</type><title>Genetic diversity and antimicrobial susceptibility of Nocardia species among patients with nocardiosis</title><source>Publicly Available Content Database</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Springer Nature - nature.com Journals - Fully Open Access</source><creator>Hashemi-Shahraki, Abodolrazagh ; Heidarieh, Parvin ; Bostanabad, Saeed Zaker ; Hashemzadeh, Mohamad ; Feizabadi, Mohamad Mehdi ; Schraufnagel, Dean ; Mirsaeidi, Mehdi</creator><creatorcontrib>Hashemi-Shahraki, Abodolrazagh ; Heidarieh, Parvin ; Bostanabad, Saeed Zaker ; Hashemzadeh, Mohamad ; Feizabadi, Mohamad Mehdi ; Schraufnagel, Dean ; Mirsaeidi, Mehdi</creatorcontrib><description>The aim of this multicenter study was to determine the genetic diversity and antibiotic susceptibility of clinically isolated Nocardia species. One hundred twenty-seven patients with nocardiosis were randomly selected from 5 provinces of Iran. Molecular diagnosis of Nocardia species was performed using multilocus sequence analysis of gyrase B of the β subunit of DNA topoisomerase ( gyrB ) and 16S rRNA and subunit A of SecA preproteintranslocase ( secA1 ). Antimicrobial susceptibility testing was performed following the Clinical and Laboratory Standards Institute recommendations. Thirty-five N. cyriacigeorgica , 30 N. asteroides , 26 N. farcinica , 12 N. otitidiscaviarum, and 10 N. abscessus cultures were studied. All isolates were susceptible to linezolid. All isolates of N. cyriacigeorgica , N. asteroides, N. abscessus and N. otitidiscaviarum were susceptible to trimethoprim-sulfamethoxazole, while 8% of N. farcinica isolates were resistant to this drug. All N. otitidiscaviarum isolates were highly resistant to imipenem, but N. cyriacigeorgica , N. asteroides, N. farcinica and N. abscessus were only moderate resistant. The susceptibility patterns vary with different species of Nocardia . Resistance to trimethoprim-sulfamethoxazole in Iran is low and this drug should be first line therapy, unless drug susceptibility testing shows resistance. Linezolid also covers Nocardia well and could be a second line agent.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep17862</identifier><identifier>PMID: 26638771</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13 ; 45 ; 45/23 ; 631/326/325/1506 ; 692/699/255/1318 ; Anti-Infective Agents - pharmacology ; Base Sequence ; Demography ; DNA topoisomerase ; Female ; Genetic diversity ; Genetic Variation ; Geography ; Humanities and Social Sciences ; Humans ; Imipenem ; Linezolid ; Male ; Microbial Sensitivity Tests ; Middle Aged ; multidisciplinary ; Nocardia - drug effects ; Nocardia - genetics ; Nocardia - isolation &amp; purification ; Nocardia Infections - microbiology ; Nocardiosis ; Nucleotide sequence ; Phylogeny ; RNA, Ribosomal, 16S - genetics ; rRNA 16S ; Science ; Species ; Species Specificity ; Sulfamethoxazole ; Trimethoprim ; Trimethoprim-sulfamethoxazole</subject><ispartof>Scientific reports, 2015-12, Vol.5 (1), p.17862-17862, Article 17862</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Dec 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-2979ebc3faa2231a8a55e22a76fd9ab735aea5ae129ccf8ebf2a1ccd29d112803</citedby><cites>FETCH-LOGICAL-c438t-2979ebc3faa2231a8a55e22a76fd9ab735aea5ae129ccf8ebf2a1ccd29d112803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1806636115/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1806636115?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,44569,53769,53771,74872</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26638771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hashemi-Shahraki, Abodolrazagh</creatorcontrib><creatorcontrib>Heidarieh, Parvin</creatorcontrib><creatorcontrib>Bostanabad, Saeed Zaker</creatorcontrib><creatorcontrib>Hashemzadeh, Mohamad</creatorcontrib><creatorcontrib>Feizabadi, Mohamad Mehdi</creatorcontrib><creatorcontrib>Schraufnagel, Dean</creatorcontrib><creatorcontrib>Mirsaeidi, Mehdi</creatorcontrib><title>Genetic diversity and antimicrobial susceptibility of Nocardia species among patients with nocardiosis</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The aim of this multicenter study was to determine the genetic diversity and antibiotic susceptibility of clinically isolated Nocardia species. One hundred twenty-seven patients with nocardiosis were randomly selected from 5 provinces of Iran. Molecular diagnosis of Nocardia species was performed using multilocus sequence analysis of gyrase B of the β subunit of DNA topoisomerase ( gyrB ) and 16S rRNA and subunit A of SecA preproteintranslocase ( secA1 ). Antimicrobial susceptibility testing was performed following the Clinical and Laboratory Standards Institute recommendations. Thirty-five N. cyriacigeorgica , 30 N. asteroides , 26 N. farcinica , 12 N. otitidiscaviarum, and 10 N. abscessus cultures were studied. All isolates were susceptible to linezolid. All isolates of N. cyriacigeorgica , N. asteroides, N. abscessus and N. otitidiscaviarum were susceptible to trimethoprim-sulfamethoxazole, while 8% of N. farcinica isolates were resistant to this drug. All N. otitidiscaviarum isolates were highly resistant to imipenem, but N. cyriacigeorgica , N. asteroides, N. farcinica and N. abscessus were only moderate resistant. The susceptibility patterns vary with different species of Nocardia . Resistance to trimethoprim-sulfamethoxazole in Iran is low and this drug should be first line therapy, unless drug susceptibility testing shows resistance. Linezolid also covers Nocardia well and could be a second line agent.</description><subject>13</subject><subject>45</subject><subject>45/23</subject><subject>631/326/325/1506</subject><subject>692/699/255/1318</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Base Sequence</subject><subject>Demography</subject><subject>DNA topoisomerase</subject><subject>Female</subject><subject>Genetic diversity</subject><subject>Genetic Variation</subject><subject>Geography</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Imipenem</subject><subject>Linezolid</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Nocardia - drug effects</subject><subject>Nocardia - genetics</subject><subject>Nocardia - isolation &amp; purification</subject><subject>Nocardia Infections - microbiology</subject><subject>Nocardiosis</subject><subject>Nucleotide sequence</subject><subject>Phylogeny</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>rRNA 16S</subject><subject>Science</subject><subject>Species</subject><subject>Species Specificity</subject><subject>Sulfamethoxazole</subject><subject>Trimethoprim</subject><subject>Trimethoprim-sulfamethoxazole</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNplkV9rFTEQxYMottQ--AUk4IsWrmayf5J9EaTYKhR90ecwm83eTtlN1iRb6bc3l1svVw0MCcyPkzNzGHsJ4h2ISr9P0S2gdCufsFMp6mYjKymfHr1P2HlKd6KcRnY1dM_ZiWzbSisFp2y8dt5lsnygexcT5QeOfiiVaSYbQ0848bQm65ZMPU07IIz8a7AYB0KeFmfJJY5z8Fu-YCbnc-K_KN9yv4dCovSCPRtxSu788T5jP64-fb_8vLn5dv3l8uPNxtaVzhvZqc71thoRpawANTaNkxJVOw4d9qpq0GEpkJ21o3b9KBGsHWQ3AEgtqjP2Ya-7rP3sBlvMRJzMEmnG-GACkvm74-nWbMO9qVsFomuKwJtHgRh-ri5lM1MZfprQu7AmA6putRJKQEFf_4PehTX6Mp4BLcqGW4Cd4Ns9VZaZSlbjwQwIswvQHAIs7Ktj9wfyT1wFuNgDqbT81sWjL_9T-w2T-6gt</recordid><startdate>20151207</startdate><enddate>20151207</enddate><creator>Hashemi-Shahraki, Abodolrazagh</creator><creator>Heidarieh, Parvin</creator><creator>Bostanabad, Saeed Zaker</creator><creator>Hashemzadeh, Mohamad</creator><creator>Feizabadi, Mohamad Mehdi</creator><creator>Schraufnagel, Dean</creator><creator>Mirsaeidi, Mehdi</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151207</creationdate><title>Genetic diversity and antimicrobial susceptibility of Nocardia species among patients with nocardiosis</title><author>Hashemi-Shahraki, Abodolrazagh ; Heidarieh, Parvin ; Bostanabad, Saeed Zaker ; Hashemzadeh, Mohamad ; Feizabadi, Mohamad Mehdi ; Schraufnagel, Dean ; Mirsaeidi, Mehdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-2979ebc3faa2231a8a55e22a76fd9ab735aea5ae129ccf8ebf2a1ccd29d112803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>13</topic><topic>45</topic><topic>45/23</topic><topic>631/326/325/1506</topic><topic>692/699/255/1318</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Base Sequence</topic><topic>Demography</topic><topic>DNA topoisomerase</topic><topic>Female</topic><topic>Genetic diversity</topic><topic>Genetic Variation</topic><topic>Geography</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Imipenem</topic><topic>Linezolid</topic><topic>Male</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Nocardia - drug effects</topic><topic>Nocardia - genetics</topic><topic>Nocardia - isolation &amp; purification</topic><topic>Nocardia Infections - microbiology</topic><topic>Nocardiosis</topic><topic>Nucleotide sequence</topic><topic>Phylogeny</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>rRNA 16S</topic><topic>Science</topic><topic>Species</topic><topic>Species Specificity</topic><topic>Sulfamethoxazole</topic><topic>Trimethoprim</topic><topic>Trimethoprim-sulfamethoxazole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashemi-Shahraki, Abodolrazagh</creatorcontrib><creatorcontrib>Heidarieh, Parvin</creatorcontrib><creatorcontrib>Bostanabad, Saeed Zaker</creatorcontrib><creatorcontrib>Hashemzadeh, Mohamad</creatorcontrib><creatorcontrib>Feizabadi, Mohamad Mehdi</creatorcontrib><creatorcontrib>Schraufnagel, Dean</creatorcontrib><creatorcontrib>Mirsaeidi, Mehdi</creatorcontrib><collection>Springer Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Databases</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashemi-Shahraki, Abodolrazagh</au><au>Heidarieh, Parvin</au><au>Bostanabad, Saeed Zaker</au><au>Hashemzadeh, Mohamad</au><au>Feizabadi, Mohamad Mehdi</au><au>Schraufnagel, Dean</au><au>Mirsaeidi, Mehdi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic diversity and antimicrobial susceptibility of Nocardia species among patients with nocardiosis</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2015-12-07</date><risdate>2015</risdate><volume>5</volume><issue>1</issue><spage>17862</spage><epage>17862</epage><pages>17862-17862</pages><artnum>17862</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The aim of this multicenter study was to determine the genetic diversity and antibiotic susceptibility of clinically isolated Nocardia species. One hundred twenty-seven patients with nocardiosis were randomly selected from 5 provinces of Iran. Molecular diagnosis of Nocardia species was performed using multilocus sequence analysis of gyrase B of the β subunit of DNA topoisomerase ( gyrB ) and 16S rRNA and subunit A of SecA preproteintranslocase ( secA1 ). Antimicrobial susceptibility testing was performed following the Clinical and Laboratory Standards Institute recommendations. Thirty-five N. cyriacigeorgica , 30 N. asteroides , 26 N. farcinica , 12 N. otitidiscaviarum, and 10 N. abscessus cultures were studied. All isolates were susceptible to linezolid. All isolates of N. cyriacigeorgica , N. asteroides, N. abscessus and N. otitidiscaviarum were susceptible to trimethoprim-sulfamethoxazole, while 8% of N. farcinica isolates were resistant to this drug. All N. otitidiscaviarum isolates were highly resistant to imipenem, but N. cyriacigeorgica , N. asteroides, N. farcinica and N. abscessus were only moderate resistant. The susceptibility patterns vary with different species of Nocardia . Resistance to trimethoprim-sulfamethoxazole in Iran is low and this drug should be first line therapy, unless drug susceptibility testing shows resistance. Linezolid also covers Nocardia well and could be a second line agent.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26638771</pmid><doi>10.1038/srep17862</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2045-2322
ispartof Scientific reports, 2015-12, Vol.5 (1), p.17862-17862, Article 17862
issn 2045-2322
2045-2322
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4671095
source Publicly Available Content Database; PubMed Central; Free Full-Text Journals in Chemistry; Springer Nature - nature.com Journals - Fully Open Access
subjects 13
45
45/23
631/326/325/1506
692/699/255/1318
Anti-Infective Agents - pharmacology
Base Sequence
Demography
DNA topoisomerase
Female
Genetic diversity
Genetic Variation
Geography
Humanities and Social Sciences
Humans
Imipenem
Linezolid
Male
Microbial Sensitivity Tests
Middle Aged
multidisciplinary
Nocardia - drug effects
Nocardia - genetics
Nocardia - isolation & purification
Nocardia Infections - microbiology
Nocardiosis
Nucleotide sequence
Phylogeny
RNA, Ribosomal, 16S - genetics
rRNA 16S
Science
Species
Species Specificity
Sulfamethoxazole
Trimethoprim
Trimethoprim-sulfamethoxazole
title Genetic diversity and antimicrobial susceptibility of Nocardia species among patients with nocardiosis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T17%3A15%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20diversity%20and%20antimicrobial%20susceptibility%20of%20Nocardia%20species%20among%20patients%20with%20nocardiosis&rft.jtitle=Scientific%20reports&rft.au=Hashemi-Shahraki,%20Abodolrazagh&rft.date=2015-12-07&rft.volume=5&rft.issue=1&rft.spage=17862&rft.epage=17862&rft.pages=17862-17862&rft.artnum=17862&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/srep17862&rft_dat=%3Cproquest_pubme%3E1746870701%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c438t-2979ebc3faa2231a8a55e22a76fd9ab735aea5ae129ccf8ebf2a1ccd29d112803%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1806636115&rft_id=info:pmid/26638771&rfr_iscdi=true