Impact of age and comorbidity on survival in colorectal cancer

Patients with colorectal cancer are often excluded from clinical trials based on age or a poor performance score. However, 70% of colorectal cancer is diagnosed in patients over 65. Evaluation on the influence of age and comorbidity on survival and cause of death in a non-selected population. Includ...

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Bibliographic Details
Published in:Journal of gastrointestinal oncology 2015-12, Vol.6 (6), p.605-612
Main Authors: van Eeghen, Elmer E, Bakker, Sandra D, van Bochove, Aart, Loffeld, Ruud J L F
Format: Article
Language:English
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Summary:Patients with colorectal cancer are often excluded from clinical trials based on age or a poor performance score. However, 70% of colorectal cancer is diagnosed in patients over 65. Evaluation on the influence of age and comorbidity on survival and cause of death in a non-selected population. Included were 621 consecutive patients with colorectal cancer. An extensive chart review was performed for 392 patients with colon cancer and 143 patients with rectal cancer. Analyses were performed separately for both groups. Median survival of colon cancer patients was 5.13 years, 131 patients (34.3%) died from tumour progression. Age and comorbidity were significant predictors for overall survival (P
ISSN:2078-6891
2219-679X
DOI:10.3978/j.issn.2078-6891.2015.070