Association between Estrogen Receptor-α Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility: A Meta-Analysis

Background. Certain studies have previously explored the association between the estrogen receptor-α (ER-α) gene polymorphisms and periodontitis susceptibility, although the current results are controversial. The present study, using meta-analysis, aimed to investigate the nature of the genetic susc...

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Bibliographic Details
Published in:Disease markers 2015-01, Vol.2015 (2015), p.1-9
Main Authors: Niu, Yu-Ming, Zuo, Hong-Xia, Yuan, Rui-Xia, Hu, Yuan-Yuan, Zhang, Chao, Weng, Hong, Yan, Jin-Zhu
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Estrogen
Estrogen Receptor alpha - genetics
Female
Gene mutations
Genetic aspects
Genetic polymorphisms
Health aspects
Homozygote
Humans
Male
Periodontitis
Periodontitis - genetics
Polymorphism, Restriction Fragment Length
Receptors
Review
Risk factors
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Summary:Background. Certain studies have previously explored the association between the estrogen receptor-α (ER-α) gene polymorphisms and periodontitis susceptibility, although the current results are controversial. The present study, using meta-analysis, aimed to investigate the nature of the genetic susceptibility of the ER-α for developing periodontitis. Methods. A comprehensive literature search of PubMed, Embase, CNKI, and Wanfang databases was conducted up to January 8, 2015. Statistical manipulation was performed using Stata version 13.0 software. Odds ratios (ORs) and corresponding 95% confident intervals (CIs) were calculated to estimate the association in five genetic models. Results. A total of 17 eligible case-control studies from seven identified publications consisting of nine studies for the XbaI polymorphism and eight studies for the PvuII polymorphism were included in the meta-analysis. We found elevated risk of periodontitis in XbaI XX genotype carriers. Moreover, subgroup analyses demonstrated increased risk for chronic periodontitis of XbaI XX genotype carriers, specifically in the Chinese Han female population. No significant association was observed between PvuII polymorphism and periodontitis. Conclusion. Current evidence indicated that the homozygote (XX) genotype of ER-α gene XbaI polymorphism, but not PvuII mutation, may increase the risk of chronic periodontitis, specifically in the Chinese Han female population.
ISSN:0278-0240
1875-8630
DOI:10.1155/2015/741972