Perinatal Oxidative Stress May Affect Fetal Ghrelin Levels in Humans

In vitro cell model studies have shown that oxidative stress may affect beta-cell function. It is unknown whether oxidative stress may affect metabolic health in human fetuses/newborns. In a singleton pregnancy cohort (n = 248), we studied maternal (24–28 weeks gestation) and cord plasma biomarkers...

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Bibliographic Details
Published in:Scientific reports 2015-12, Vol.5 (1), p.17881-17881, Article 17881
Main Authors: Luo, Zhong-Cheng, Bilodeau, Jean-François, Monique Nuyt, Anne, Fraser, William D., Julien, Pierre, Audibert, Francois, Xiao, Lin, Garofalo, Carole, Levy, Emile
Format: Article
Language:English
Subjects:
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Adiponectin
Adult
Beta cells
Biomarkers
F2-Isoprostanes - blood
F2-Isoprostanes - metabolism
Female
Fetal Blood - metabolism
Fetus - metabolism
Fetuses
Gestational Age
Ghrelin
Ghrelin - blood
Ghrelin - metabolism
Humanities and Social Sciences
Humans
Infant, Newborn
Insulin
Insulin-like growth factor I
Insulin-like growth factor II
Insulin-Secreting Cells
Isoprostanes
Leptin
Malondialdehyde
Malondialdehyde - blood
Malondialdehyde - metabolism
Metabolic disorders
Metabolic syndrome
Metabolism
multidisciplinary
Neonates
Oxidative Stress
Pregnancy
Science
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Summary:In vitro cell model studies have shown that oxidative stress may affect beta-cell function. It is unknown whether oxidative stress may affect metabolic health in human fetuses/newborns. In a singleton pregnancy cohort (n = 248), we studied maternal (24–28 weeks gestation) and cord plasma biomarkers of oxidative stress [malondialdehyde (MDA), F2-isoprostanes] in relation to fetal metabolic health biomarkers including cord plasma glucose-to-insulin ratio (an indicator of insulin sensitivity), proinsulin-to-insulin ratio (an indicator of beta-cell function), insulin, IGF-I, IGF-II, leptin, adiponectin and ghrelin concentrations. Strong positive correlations were observed between maternal and cord plasma biomarkers of oxidative stress (r = 0.33 for MDA, r = 0.74 for total F2-isoprostanes, all p 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep17881