Coincident liposarcoma, carcinoid and gastrointestinal stromal tumor complicating type 1 neurofibromatosis: Case report and literature review

Abstract Neurofibromatosis type 1 (NF1) is associated with increased risk of multiple neoplasms. We present a case of a female patient with NF1 who presented with a rectal low-grade neuroendocrine (carcinoid) tumor. Computed tomography imaging found a well-differentiated liposarcoma and a well-circu...

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Bibliographic Details
Published in:Journal of orthopaedics 2015-10, Vol.12 (Suppl 1), p.S111-S116
Main Authors: James, Aaron W, Chang, Le, Genshaft, Scott, Dry, Sarah M
Format: Article
Language:English
Subjects:
Carcinoid
GIST
Malignant peripheral nerve sheath tumor
Orthopedics
Review
Type 1 neurofibromatosis
Well-differentiated liposarcoma
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Summary:Abstract Neurofibromatosis type 1 (NF1) is associated with increased risk of multiple neoplasms. We present a case of a female patient with NF1 who presented with a rectal low-grade neuroendocrine (carcinoid) tumor. Computed tomography imaging found a well-differentiated liposarcoma and a well-circumscribed gastro-intestinal stromal tumor (GIST). Although GIST and carcinoid tumors are frequently found in NF1 patients, liposarcoma complicating NF1 is quite rare and this is the first reported case of well-differentiated liposarcoma in NF1. In summary, we report a case of coincident abdominal carcinoid tumor, GIST and well-differentiated liposarcoma, which illustrates the variability of neoplasms in NF1 patients.
ISSN:0972-978X
0972-978X
DOI:10.1016/j.jor.2014.08.010