Loading…
Hippocampal dosimetry correlates with the change in neurocognitive function after hippocampal sparing during whole brain radiotherapy: a prospective study
Whole brain radiotherapy (WBRT) has been the treatment of choice for patients with brain metastases. However, change/decline of neurocognitive functions (NCFs) resulting from impaired hippocampal neurogenesis might occur after WBRT. It is reported that conformal hippocampal sparing would provide the...
Saved in:
| Published in: | Radiation oncology (London, England) England), 2015-12, Vol.10 (1), p.253-253, Article 253 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c494t-7c9660e561bdea685b180ff4173d25233459503cbc41066d3f109f3393bd1c143 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c494t-7c9660e561bdea685b180ff4173d25233459503cbc41066d3f109f3393bd1c143 |
| container_end_page | 253 |
| container_issue | 1 |
| container_start_page | 253 |
| container_title | Radiation oncology (London, England) |
| container_volume | 10 |
| creator | Tsai, Ping-Fang Yang, Chi-Cheng Chuang, Chi-Cheng Huang, Ting-Yi Wu, Yi-Ming Pai, Ping-Ching Tseng, Chen-Kan Wu, Tung-Ho Shen, Yi-Liang Lin, Shinn-Yn |
| description | Whole brain radiotherapy (WBRT) has been the treatment of choice for patients with brain metastases. However, change/decline of neurocognitive functions (NCFs) resulting from impaired hippocampal neurogenesis might occur after WBRT. It is reported that conformal hippocampal sparing would provide the preservation of NCFs. Our study aims to investigate the hippocampal dosimetry and to demonstrate the correlation between hippocampal dosimetry and neurocognitive outcomes in patients receiving hippocampal sparing during WBRT (HS-WBRT).
Forty prospectively recruited cancer patients underwent HS-WBRT for therapeutic or prophylactic purposes. Before receiving HS-WBRT, all participants received a battery of baseline neurocognitive assessment, including memory, executive functions and psychomotor speed. The follow-up neurocognitive assessment at 4 months after HS-WBRT was also performed. For the delivery of HS-WBRT, Volumetric Modulated Arc Therapy (VMAT) with two full arcs and two non-coplanar partial arcs was employed. For each treatment planning, dose volume histograms were generated for left hippocampus, right hippocampus, and the composite hippocampal structure respectively. Biologically equivalent doses in 2-Gy fractions (EQD2) assuming an alpha/beta ratio of 2 Gy were computed. To perform analyses addressing the correlation between hippocampal dosimetry and the change in scores of NCFs, pre- and post-HS-WBRT neurocognitive assessments were available in 24 patients in this study.
Scores of NCFs were quite stable before and after HS-WBRT in terms of hippocampus-dependent memory. Regarding verbal memory, the corresponding EQD2 values of 0, 10, 50, 80 % irradiating the composite hippocampal structure with |
| doi_str_mv | 10.1186/s13014-015-0562-x |
| format | article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4676088</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A468953302</galeid><sourcerecordid>A468953302</sourcerecordid><originalsourceid>FETCH-LOGICAL-c494t-7c9660e561bdea685b180ff4173d25233459503cbc41066d3f109f3393bd1c143</originalsourceid><addsrcrecordid>eNptkl9v1SAYxhujcXP6AbwxJN7sphPKnxYvTJZF3ZIl3mjiHaH0bcvSQgW67XwVP62cnbmdGcPFS-B5fvDCUxRvCT4hpBEfIqGYsBITXmIuqvL2WXFIataUNal_Pt-bHxSvYrzCmHGK5cvioBKCM1I1h8Xvc7ss3uh50RPqfLQzpLBBxocAk04Q0Y1NI0ojIDNqNwCyDjlYgzd-cDbZa0D96kyy3iHdJwho3CPGRQfrBtStd-Vm9BOgNugMCbqzPnODXjYfkUZL8HEBc0eMae02r4sXvZ4ivLmvR8WPL5-_n52Xl9--XpydXpaGSZbK2kghMHBB2g60aHhLGtz3jNS0q3hFKeOSY2pawwgWoqM9wbKnVNK2I4YwelR82nGXtZ2hM-BS0JNagp112CivrXq64-yoBn-tmKgFbpoMOL4HBP9rhZjUbKOBadIO_BpV_gYppeB0K33_j_TKr8Hl9rKqliLfsJaPqkFPoKzrfT7XbKHqlIlGckpxlVUn_1Hl0cFsjXfQ27z-xEB2BpOfOgboH3okWG0DpXaBUjlQahsodZs97_Yf58HxN0H0D5sbyfY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1779610679</pqid></control><display><type>article</type><title>Hippocampal dosimetry correlates with the change in neurocognitive function after hippocampal sparing during whole brain radiotherapy: a prospective study</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Tsai, Ping-Fang ; Yang, Chi-Cheng ; Chuang, Chi-Cheng ; Huang, Ting-Yi ; Wu, Yi-Ming ; Pai, Ping-Ching ; Tseng, Chen-Kan ; Wu, Tung-Ho ; Shen, Yi-Liang ; Lin, Shinn-Yn</creator><creatorcontrib>Tsai, Ping-Fang ; Yang, Chi-Cheng ; Chuang, Chi-Cheng ; Huang, Ting-Yi ; Wu, Yi-Ming ; Pai, Ping-Ching ; Tseng, Chen-Kan ; Wu, Tung-Ho ; Shen, Yi-Liang ; Lin, Shinn-Yn</creatorcontrib><description>Whole brain radiotherapy (WBRT) has been the treatment of choice for patients with brain metastases. However, change/decline of neurocognitive functions (NCFs) resulting from impaired hippocampal neurogenesis might occur after WBRT. It is reported that conformal hippocampal sparing would provide the preservation of NCFs. Our study aims to investigate the hippocampal dosimetry and to demonstrate the correlation between hippocampal dosimetry and neurocognitive outcomes in patients receiving hippocampal sparing during WBRT (HS-WBRT).
Forty prospectively recruited cancer patients underwent HS-WBRT for therapeutic or prophylactic purposes. Before receiving HS-WBRT, all participants received a battery of baseline neurocognitive assessment, including memory, executive functions and psychomotor speed. The follow-up neurocognitive assessment at 4 months after HS-WBRT was also performed. For the delivery of HS-WBRT, Volumetric Modulated Arc Therapy (VMAT) with two full arcs and two non-coplanar partial arcs was employed. For each treatment planning, dose volume histograms were generated for left hippocampus, right hippocampus, and the composite hippocampal structure respectively. Biologically equivalent doses in 2-Gy fractions (EQD2) assuming an alpha/beta ratio of 2 Gy were computed. To perform analyses addressing the correlation between hippocampal dosimetry and the change in scores of NCFs, pre- and post-HS-WBRT neurocognitive assessments were available in 24 patients in this study.
Scores of NCFs were quite stable before and after HS-WBRT in terms of hippocampus-dependent memory. Regarding verbal memory, the corresponding EQD2 values of 0, 10, 50, 80 % irradiating the composite hippocampal structure with <12.60 Gy, <8.81, <7.45 Gy and <5.83 Gy respectively were significantly associated with neurocognitive preservation indicated by the immediate recall of Word List Test of Wechsler Memory Scale-III. According to logistic regression analyses, it was noted that dosimetric parameters specific to left sided hippocampus exerted an influence on immediate recall of verbal memory (adjusted odds ratio, 4.08; p-value, 0.042, predicting patients' neurocognitive decline after receiving HS-WBRT).
Functional preservation by hippocampal sparing during WBRT is indeed achieved in our study. Providing that modern VMAT techniques can reduce the dose irradiating bilateral hippocampi below dosimetric threshold, patients should be recruited in prospective trials of hippocampal sparing during cranial irradiation to accomplish neurocognitive preservation while maintaining intracranial control.
Current Controlled Trials NCT02504788.</description><identifier>ISSN: 1748-717X</identifier><identifier>EISSN: 1748-717X</identifier><identifier>DOI: 10.1186/s13014-015-0562-x</identifier><identifier>PMID: 26654128</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Analysis ; Batteries ; Brain ; Brain Neoplasms - radiotherapy ; Care and treatment ; Cognition - radiation effects ; Cranial Irradiation - adverse effects ; Cranial Irradiation - methods ; Health aspects ; Hippocampus - radiation effects ; Humans ; Metastasis ; Neuropsychological Tests ; Prospective Studies ; Radiation Injuries - prevention & control ; Radiometry ; Radiotherapy ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Intensity-Modulated</subject><ispartof>Radiation oncology (London, England), 2015-12, Vol.10 (1), p.253-253, Article 253</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2015</rights><rights>Tsai et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-7c9660e561bdea685b180ff4173d25233459503cbc41066d3f109f3393bd1c143</citedby><cites>FETCH-LOGICAL-c494t-7c9660e561bdea685b180ff4173d25233459503cbc41066d3f109f3393bd1c143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676088/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1779610679?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26654128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsai, Ping-Fang</creatorcontrib><creatorcontrib>Yang, Chi-Cheng</creatorcontrib><creatorcontrib>Chuang, Chi-Cheng</creatorcontrib><creatorcontrib>Huang, Ting-Yi</creatorcontrib><creatorcontrib>Wu, Yi-Ming</creatorcontrib><creatorcontrib>Pai, Ping-Ching</creatorcontrib><creatorcontrib>Tseng, Chen-Kan</creatorcontrib><creatorcontrib>Wu, Tung-Ho</creatorcontrib><creatorcontrib>Shen, Yi-Liang</creatorcontrib><creatorcontrib>Lin, Shinn-Yn</creatorcontrib><title>Hippocampal dosimetry correlates with the change in neurocognitive function after hippocampal sparing during whole brain radiotherapy: a prospective study</title><title>Radiation oncology (London, England)</title><addtitle>Radiat Oncol</addtitle><description>Whole brain radiotherapy (WBRT) has been the treatment of choice for patients with brain metastases. However, change/decline of neurocognitive functions (NCFs) resulting from impaired hippocampal neurogenesis might occur after WBRT. It is reported that conformal hippocampal sparing would provide the preservation of NCFs. Our study aims to investigate the hippocampal dosimetry and to demonstrate the correlation between hippocampal dosimetry and neurocognitive outcomes in patients receiving hippocampal sparing during WBRT (HS-WBRT).
Forty prospectively recruited cancer patients underwent HS-WBRT for therapeutic or prophylactic purposes. Before receiving HS-WBRT, all participants received a battery of baseline neurocognitive assessment, including memory, executive functions and psychomotor speed. The follow-up neurocognitive assessment at 4 months after HS-WBRT was also performed. For the delivery of HS-WBRT, Volumetric Modulated Arc Therapy (VMAT) with two full arcs and two non-coplanar partial arcs was employed. For each treatment planning, dose volume histograms were generated for left hippocampus, right hippocampus, and the composite hippocampal structure respectively. Biologically equivalent doses in 2-Gy fractions (EQD2) assuming an alpha/beta ratio of 2 Gy were computed. To perform analyses addressing the correlation between hippocampal dosimetry and the change in scores of NCFs, pre- and post-HS-WBRT neurocognitive assessments were available in 24 patients in this study.
Scores of NCFs were quite stable before and after HS-WBRT in terms of hippocampus-dependent memory. Regarding verbal memory, the corresponding EQD2 values of 0, 10, 50, 80 % irradiating the composite hippocampal structure with <12.60 Gy, <8.81, <7.45 Gy and <5.83 Gy respectively were significantly associated with neurocognitive preservation indicated by the immediate recall of Word List Test of Wechsler Memory Scale-III. According to logistic regression analyses, it was noted that dosimetric parameters specific to left sided hippocampus exerted an influence on immediate recall of verbal memory (adjusted odds ratio, 4.08; p-value, 0.042, predicting patients' neurocognitive decline after receiving HS-WBRT).
Functional preservation by hippocampal sparing during WBRT is indeed achieved in our study. Providing that modern VMAT techniques can reduce the dose irradiating bilateral hippocampi below dosimetric threshold, patients should be recruited in prospective trials of hippocampal sparing during cranial irradiation to accomplish neurocognitive preservation while maintaining intracranial control.
Current Controlled Trials NCT02504788.</description><subject>Analysis</subject><subject>Batteries</subject><subject>Brain</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Care and treatment</subject><subject>Cognition - radiation effects</subject><subject>Cranial Irradiation - adverse effects</subject><subject>Cranial Irradiation - methods</subject><subject>Health aspects</subject><subject>Hippocampus - radiation effects</subject><subject>Humans</subject><subject>Metastasis</subject><subject>Neuropsychological Tests</subject><subject>Prospective Studies</subject><subject>Radiation Injuries - prevention & control</subject><subject>Radiometry</subject><subject>Radiotherapy</subject><subject>Radiotherapy Planning, Computer-Assisted</subject><subject>Radiotherapy, Intensity-Modulated</subject><issn>1748-717X</issn><issn>1748-717X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptkl9v1SAYxhujcXP6AbwxJN7sphPKnxYvTJZF3ZIl3mjiHaH0bcvSQgW67XwVP62cnbmdGcPFS-B5fvDCUxRvCT4hpBEfIqGYsBITXmIuqvL2WXFIataUNal_Pt-bHxSvYrzCmHGK5cvioBKCM1I1h8Xvc7ss3uh50RPqfLQzpLBBxocAk04Q0Y1NI0ojIDNqNwCyDjlYgzd-cDbZa0D96kyy3iHdJwho3CPGRQfrBtStd-Vm9BOgNugMCbqzPnODXjYfkUZL8HEBc0eMae02r4sXvZ4ivLmvR8WPL5-_n52Xl9--XpydXpaGSZbK2kghMHBB2g60aHhLGtz3jNS0q3hFKeOSY2pawwgWoqM9wbKnVNK2I4YwelR82nGXtZ2hM-BS0JNagp112CivrXq64-yoBn-tmKgFbpoMOL4HBP9rhZjUbKOBadIO_BpV_gYppeB0K33_j_TKr8Hl9rKqliLfsJaPqkFPoKzrfT7XbKHqlIlGckpxlVUn_1Hl0cFsjXfQ27z-xEB2BpOfOgboH3okWG0DpXaBUjlQahsodZs97_Yf58HxN0H0D5sbyfY</recordid><startdate>20151210</startdate><enddate>20151210</enddate><creator>Tsai, Ping-Fang</creator><creator>Yang, Chi-Cheng</creator><creator>Chuang, Chi-Cheng</creator><creator>Huang, Ting-Yi</creator><creator>Wu, Yi-Ming</creator><creator>Pai, Ping-Ching</creator><creator>Tseng, Chen-Kan</creator><creator>Wu, Tung-Ho</creator><creator>Shen, Yi-Liang</creator><creator>Lin, Shinn-Yn</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151210</creationdate><title>Hippocampal dosimetry correlates with the change in neurocognitive function after hippocampal sparing during whole brain radiotherapy: a prospective study</title><author>Tsai, Ping-Fang ; Yang, Chi-Cheng ; Chuang, Chi-Cheng ; Huang, Ting-Yi ; Wu, Yi-Ming ; Pai, Ping-Ching ; Tseng, Chen-Kan ; Wu, Tung-Ho ; Shen, Yi-Liang ; Lin, Shinn-Yn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-7c9660e561bdea685b180ff4173d25233459503cbc41066d3f109f3393bd1c143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analysis</topic><topic>Batteries</topic><topic>Brain</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>Care and treatment</topic><topic>Cognition - radiation effects</topic><topic>Cranial Irradiation - adverse effects</topic><topic>Cranial Irradiation - methods</topic><topic>Health aspects</topic><topic>Hippocampus - radiation effects</topic><topic>Humans</topic><topic>Metastasis</topic><topic>Neuropsychological Tests</topic><topic>Prospective Studies</topic><topic>Radiation Injuries - prevention & control</topic><topic>Radiometry</topic><topic>Radiotherapy</topic><topic>Radiotherapy Planning, Computer-Assisted</topic><topic>Radiotherapy, Intensity-Modulated</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsai, Ping-Fang</creatorcontrib><creatorcontrib>Yang, Chi-Cheng</creatorcontrib><creatorcontrib>Chuang, Chi-Cheng</creatorcontrib><creatorcontrib>Huang, Ting-Yi</creatorcontrib><creatorcontrib>Wu, Yi-Ming</creatorcontrib><creatorcontrib>Pai, Ping-Ching</creatorcontrib><creatorcontrib>Tseng, Chen-Kan</creatorcontrib><creatorcontrib>Wu, Tung-Ho</creatorcontrib><creatorcontrib>Shen, Yi-Liang</creatorcontrib><creatorcontrib>Lin, Shinn-Yn</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Radiation oncology (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsai, Ping-Fang</au><au>Yang, Chi-Cheng</au><au>Chuang, Chi-Cheng</au><au>Huang, Ting-Yi</au><au>Wu, Yi-Ming</au><au>Pai, Ping-Ching</au><au>Tseng, Chen-Kan</au><au>Wu, Tung-Ho</au><au>Shen, Yi-Liang</au><au>Lin, Shinn-Yn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hippocampal dosimetry correlates with the change in neurocognitive function after hippocampal sparing during whole brain radiotherapy: a prospective study</atitle><jtitle>Radiation oncology (London, England)</jtitle><addtitle>Radiat Oncol</addtitle><date>2015-12-10</date><risdate>2015</risdate><volume>10</volume><issue>1</issue><spage>253</spage><epage>253</epage><pages>253-253</pages><artnum>253</artnum><issn>1748-717X</issn><eissn>1748-717X</eissn><abstract>Whole brain radiotherapy (WBRT) has been the treatment of choice for patients with brain metastases. However, change/decline of neurocognitive functions (NCFs) resulting from impaired hippocampal neurogenesis might occur after WBRT. It is reported that conformal hippocampal sparing would provide the preservation of NCFs. Our study aims to investigate the hippocampal dosimetry and to demonstrate the correlation between hippocampal dosimetry and neurocognitive outcomes in patients receiving hippocampal sparing during WBRT (HS-WBRT).
Forty prospectively recruited cancer patients underwent HS-WBRT for therapeutic or prophylactic purposes. Before receiving HS-WBRT, all participants received a battery of baseline neurocognitive assessment, including memory, executive functions and psychomotor speed. The follow-up neurocognitive assessment at 4 months after HS-WBRT was also performed. For the delivery of HS-WBRT, Volumetric Modulated Arc Therapy (VMAT) with two full arcs and two non-coplanar partial arcs was employed. For each treatment planning, dose volume histograms were generated for left hippocampus, right hippocampus, and the composite hippocampal structure respectively. Biologically equivalent doses in 2-Gy fractions (EQD2) assuming an alpha/beta ratio of 2 Gy were computed. To perform analyses addressing the correlation between hippocampal dosimetry and the change in scores of NCFs, pre- and post-HS-WBRT neurocognitive assessments were available in 24 patients in this study.
Scores of NCFs were quite stable before and after HS-WBRT in terms of hippocampus-dependent memory. Regarding verbal memory, the corresponding EQD2 values of 0, 10, 50, 80 % irradiating the composite hippocampal structure with <12.60 Gy, <8.81, <7.45 Gy and <5.83 Gy respectively were significantly associated with neurocognitive preservation indicated by the immediate recall of Word List Test of Wechsler Memory Scale-III. According to logistic regression analyses, it was noted that dosimetric parameters specific to left sided hippocampus exerted an influence on immediate recall of verbal memory (adjusted odds ratio, 4.08; p-value, 0.042, predicting patients' neurocognitive decline after receiving HS-WBRT).
Functional preservation by hippocampal sparing during WBRT is indeed achieved in our study. Providing that modern VMAT techniques can reduce the dose irradiating bilateral hippocampi below dosimetric threshold, patients should be recruited in prospective trials of hippocampal sparing during cranial irradiation to accomplish neurocognitive preservation while maintaining intracranial control.
Current Controlled Trials NCT02504788.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26654128</pmid><doi>10.1186/s13014-015-0562-x</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1748-717X |
| ispartof | Radiation oncology (London, England), 2015-12, Vol.10 (1), p.253-253, Article 253 |
| issn | 1748-717X 1748-717X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4676088 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Analysis Batteries Brain Brain Neoplasms - radiotherapy Care and treatment Cognition - radiation effects Cranial Irradiation - adverse effects Cranial Irradiation - methods Health aspects Hippocampus - radiation effects Humans Metastasis Neuropsychological Tests Prospective Studies Radiation Injuries - prevention & control Radiometry Radiotherapy Radiotherapy Planning, Computer-Assisted Radiotherapy, Intensity-Modulated |
| title | Hippocampal dosimetry correlates with the change in neurocognitive function after hippocampal sparing during whole brain radiotherapy: a prospective study |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T19%3A09%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hippocampal%20dosimetry%20correlates%20with%20the%20change%20in%20neurocognitive%20function%20after%20hippocampal%20sparing%20during%20whole%20brain%20radiotherapy:%20a%20prospective%20study&rft.jtitle=Radiation%20oncology%20(London,%20England)&rft.au=Tsai,%20Ping-Fang&rft.date=2015-12-10&rft.volume=10&rft.issue=1&rft.spage=253&rft.epage=253&rft.pages=253-253&rft.artnum=253&rft.issn=1748-717X&rft.eissn=1748-717X&rft_id=info:doi/10.1186/s13014-015-0562-x&rft_dat=%3Cgale_pubme%3EA468953302%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c494t-7c9660e561bdea685b180ff4173d25233459503cbc41066d3f109f3393bd1c143%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1779610679&rft_id=info:pmid/26654128&rft_galeid=A468953302&rfr_iscdi=true |