Effects of the physicochemical properties of gold nanostructures on cellular internalization

Unique physicochemical properties of Au nanomaterials make them potential star materials in biomedical applications. However, we still know a little about the basic problem of what really matters in fabrication of Au nanomaterials which can get into biological systems, especially cells, with high ef...

Full description

Saved in:
Bibliographic Details
Published in:Regenerative biomaterials 2015-12, Vol.2 (4), p.273-280
Main Authors: Gong, Ningqiang, Chen, Shizhu, Jin, Shubin, Zhang, Jinchao, Wang, Paul C., Liang, Xing-Jie
Format: Article
Language:English
Subjects:
Reviews
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Unique physicochemical properties of Au nanomaterials make them potential star materials in biomedical applications. However, we still know a little about the basic problem of what really matters in fabrication of Au nanomaterials which can get into biological systems, especially cells, with high efficiency. An understanding of how the physicochemical properties of Au nanomaterials affect their cell internalization is of significant interest. Studies devoted to clarify the functions of various properties of Au nanostructures such as size, shape and kinds of surface characteristics in cell internalization are under way. These fundamental investigations will give us a foundation for constructing Au nanomaterial-based biomedical devices in the future. In this review, we present the current advances and rationales in study of the relationship between the physicochemical properties of Au nanomaterials and cell uptake. We also provide a perspective on the Au nanomaterial-cell interaction research.
ISSN:2056-3418
2056-3426
DOI:10.1093/rb/rbv024