Training Status as a Marker of the Relationship between Nitric Oxide, Oxidative Stress, and Blood Pressure in Older Adult Women

The purpose of this study was to evaluate the influence of functional fitness and oxidative capacity on the nitric oxide concentration associated with hemodynamic control in older adult women. The sample consisted of 134 women (65.73 ± 6.14 years old). All subjects underwent a physical examination t...

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Published in:Oxidative medicine and cellular longevity 2016-01, Vol.2016 (2016), p.1-9
Main Authors: Tanus-Santos, José Eduardo, Lia do Amaral, Sandra, Saranz Zago, Anderson, Alexandre Trapé, Atila, Fernanda da Silva, Roberta, Bernardino da Silva, Anderson, Cezar Pinheiro, Lucas, de Oliveira Brito, Janaina, da Silva Dias, Danielle, Celso Dutra de Souza, Hugo, Mourão Jacomini, André, De Angelis, Kátia
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Aged
Aged women
Antioxidants
Bioavailability
Blood pressure
Blood Pressure - physiology
Body Mass Index
Enzymes
Exercise
Exercise Test
Female
Health aspects
Humans
Middle Aged
Nitric oxide
Nitric Oxide - analysis
Older people
Oxidative Stress
Oxygen Consumption
Physical fitness
Physiological aspects
Studies
Superoxide Dismutase - metabolism
Waist-Hip Ratio
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Summary:The purpose of this study was to evaluate the influence of functional fitness and oxidative capacity on the nitric oxide concentration associated with hemodynamic control in older adult women. The sample consisted of 134 women (65.73 ± 6.14 years old). All subjects underwent a physical examination to assess body mass index, waist-hip ratio, body fat measurement by dual energy X-ray absorptiometry, and blood pressure (BP). Training status (TS) was evaluated by indirect determination of maximal oxygen uptake by a treadmill test using Balke protocol modified for older adults. Functional fitness was also evaluated through a “Functional Fitness Battery Test” to determine the general fitness functional index (GFFI). All participants were separated according to the functional fitness (TS1, very weak and weak; TS2, regular; TS3, good and very good). Plasma blood samples were used to evaluate prooxidant and antioxidant activity and nitrite and nitrate concentrations. The general results of this study showed that good levels of TS were related to lower levels of lipoperoxidation and protein damage, higher levels of antioxidant, and higher concentration of nitrite and nitrate. This combination may be responsible for the lower levels of BP in subjects with better TS.
ISSN:1942-0900
1942-0994
DOI:10.1155/2016/8262383