No evidence for viral sequences in five lepidic adenocarcinomas (former "BAC") by a high-throughput sequencing approach

The hypothesis of an infectious etiology of the formerly named bronchiolo-alveolar carcinoma (BAC) has raised controversy. We investigated tumor lung tissues from five patients with former BAC histology using high-throughput sequencing technologies to discover potential viruses present in this type...

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Bibliographic Details
Published in:BMC research notes 2015-12, Vol.8 (1), p.782-782, Article 782
Main Authors: Berthet, Nicolas, Frangeul, Lionel, Olaussen, Ken André, Brambilla, Elisabeth, Dorvault, Nicolas, Girard, Philippe, Validire, Pierre, Fadel, Elie, Bouchier, Christiane, Gessain, Antoine, Soria, Jean-Charles
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - genetics
Adenocarcinoma - virology
Adenocarcinoma, Bronchiolo-Alveolar
Adenocarcinoma, Bronchiolo-Alveolar - genetics
Adenocarcinoma, Bronchiolo-Alveolar - virology
Aged
Analysis
Animals
Biochemistry, Molecular Biology
Bioinformatics
Computer Science
Development and progression
Endogenous Retroviruses
Endogenous Retroviruses - genetics
Endogenous Retroviruses - physiology
Female
Genomics
High-Throughput Nucleotide Sequencing
High-Throughput Nucleotide Sequencing - methods
Humans
Jaagsiekte sheep retrovirus
Jaagsiekte sheep retrovirus - genetics
Jaagsiekte sheep retrovirus - physiology
Life Sciences
Lung
Lung - pathology
Lung - virology
Lung cancer
Lung Neoplasms
Lung Neoplasms - genetics
Lung Neoplasms - virology
Male
Microbiology and Parasitology
Middle Aged
Pulmonary Adenomatosis, Ovine
Pulmonary Adenomatosis, Ovine - genetics
Pulmonary Adenomatosis, Ovine - virology
Sheep
Virology
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Summary:The hypothesis of an infectious etiology of the formerly named bronchiolo-alveolar carcinoma (BAC) has raised controversy. We investigated tumor lung tissues from five patients with former BAC histology using high-throughput sequencing technologies to discover potential viruses present in this type of lung cancer. Around 180 million single reads of 100 bases were generated for each BAC sample. None of the reads showed a significant similarity for Jaagsiekte sheep retrovirus (JSRV) and no other viruses were found except for endogenous retroviruses. In conclusion, we have demonstrated the absence of JSRV and other known human viruses in five samples of well-characterized lepidic adenocarcinoma.
ISSN:1756-0500
1756-0500
DOI:10.1186/s13104-015-1669-8