GABAergic modulation with classical benzodiazepines prevent stress-induced neuro-immune dysregulation and behavioral alterations

• Published in: Brain, behavior, and immunity behavior, and immunity, 2016-01, Vol.51, p.154-168
• Main Authors: Ramirez, Karol, Niraula, Anzela, Sheridan, John F
• Format: Article
• Language: English
• Subjects: Allergy and Immunology; Animals; Anti-Anxiety Agents - administration & dosage; Anxiety - etiology; Anxiety - immunology; Anxiety-like behavior; Behavior, Animal - drug effects; Benzodiazepines; Bone Marrow - drug effects; Brain - drug effects; Brain - immunology; CD11b Antigen - metabolism; Clonazepam - administration & dosage; Corticosterone - blood; Corticotropin-Releasing Hormone - metabolism; GABA Modulators - administration & dosage; Granulocytes - drug effects; Hematopoiesis - drug effects; Hippocampus - drug effects; Hippocampus - immunology; Hypothalamus - drug effects; Hypothalamus - immunology; Interleukin-6 - blood; Lorazepam - administration & dosage; Male; Mice; Mice, Inbred C57BL; Microglia; Microglia - drug effects; Microglia - immunology; Monocytes - drug effects; Psychiatry; Psychosocial stress; RNA, Messenger - metabolism; Social avoidance; Social defeat; Splenomegaly - etiology; Splenomegaly - prevention & control; Stress, Psychological - complications; Stress, Psychological - immunology
• ISSN: 0889-1591; 1090-2139
• DOI: 10.1016/j.bbi.2015.08.011

Highlights • Classical benzodiazepines ameliorated stress-induced neuroimmune responses. • Lorazepam and clonazepam blocked stress-induced neuroinflammatory signaling. • Classical benzodiazepines reversed anxiety-like and depressive-like behavior.