The investigation of glucose metabolism and insulin secretion in subjects of chronic hepatitis B with cirrhosis

To investigate the situations of abnormal glucose metabolism and dysfunction of pancreatic islet beta cells in subjects of chronic hepatitis B (CHB) with cirrhosis. 106 hepatitis B virus (HBV) positive subjects with liver cirrhosis as well as with different grade of Child-Pugh and 37 healthy subject...

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Bibliographic Details
Published in:International journal of clinical and experimental pathology 2015-01, Vol.8 (10), p.13381-13386
Main Authors: Guo, Chun-Hui, Sun, Ting-Ting, Weng, Xi-Ding, Zhang, Jian-Chun, Chen, Jian-Xin, Deng, Guo-Jiong
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Glucose - analysis
C-Peptide - blood
Female
Glucose - metabolism
Glucose Tolerance Test
Hepatitis B, Chronic - complications
Humans
Insulin - blood
Insulin - metabolism
Insulin Resistance - physiology
Insulin Secretion
Liver Cirrhosis - metabolism
Liver Cirrhosis - virology
Male
Middle Aged
Original
Pancreas - metabolism
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Summary:To investigate the situations of abnormal glucose metabolism and dysfunction of pancreatic islet beta cells in subjects of chronic hepatitis B (CHB) with cirrhosis. 106 hepatitis B virus (HBV) positive subjects with liver cirrhosis as well as with different grade of Child-Pugh and 37 healthy subjects were included in this study. The oral glucose tolerance test (OGTT), C-peptide and insulin release test were detected. Plasma glucose and insulin levels were analyzed periodically for 2 h after oral glucose loading. There was no significant difference in the level of fasting plasma glucose and C-peptide between cirrhosis group and control group (P>0.05). The levels of OGTT 2 h glucose, insulin and C peptide were significantly higher in cirrhosis group than control group (P
ISSN:1936-2625