Chronic myeloid leukemia with variation of translocation at (Ph) [ins (22;9) (q11;q21q34)]: a case report

Chronic myeloid leukemia (CML) is most frequently observed in middle-aged individuals. In most patients, normal marrow cells are replaced by cells with an abnormal G-group chromosome, the Philadelphia (Ph) chromosome. The Ph chromosome that is characterized by the translocation (9;22) (q34;q11) is n...

Full description

Saved in:
Bibliographic Details
Published in:International journal of clinical and experimental pathology 2015-01, Vol.8 (10), p.13707-13710
Main Authors: Wang, Zhiqiong, Zen, Wen, Meng, Fankai, Xin, Xing, Luo, Li, Sun, Hanying, Zhou, Jianfeng, Huang, Lifang
Format: Article
Language:English
Subjects:
Adult
Bone Marrow Cells
Case Report
Chromosome Aberrations
Chromosomes, Human, Pair 22 - genetics
Chromosomes, Human, Pair 9 - genetics
Female
Humans
Karyotype
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Mutagenesis, Insertional
Philadelphia Chromosome
Translocation, Genetic
Treatment Outcome
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chronic myeloid leukemia (CML) is most frequently observed in middle-aged individuals. In most patients, normal marrow cells are replaced by cells with an abnormal G-group chromosome, the Philadelphia (Ph) chromosome. The Ph chromosome that is characterized by the translocation (9;22) (q34;q11) is noted in 90-95% of patients diagnosed with CML. Studies have also shown that CML can be associated with various other cytogenetic abnormalities, with 5-10% of these cases showing complex translocation involving another chromosome in addition to the Ph chromosome. Here, we report the case of a Ph(+) CML patient with an inserted karyotype who presented clinically in the chronic phase but with atypical features. This case highlights the significance of cytogenetic abnormalities on the prognosis in CML.
ISSN:1936-2625