Aryl hydrocarbon receptor: Linking environment to immunity

Highlights • AHR links environmental clues to host immune responses. • AHR is activated by exogenous and endogenous ligands; their interplay is still poorly understood. • Different AHR ligands may differentially influence autoimmune diseases. • AHR signaling affects multiple immune cell types, inclu...

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Bibliographic Details
Published in:Seminars in immunology 2015-09, Vol.27 (5), p.310-314
Main Authors: Cella, Marina, Colonna, Marco
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Aryl hydrocarbon receptor
Dendritic Cells - immunology
Dendritic Cells - metabolism
Environment
Humans
IL-22
Immune System - immunology
Immune System - metabolism
Immunity
Immunity, Innate
Innate lymphoid cells
Ligands
Lymphocyte Subsets - immunology
Lymphocyte Subsets - metabolism
Mucosal tissues
Organ Specificity - genetics
Receptors, Aryl Hydrocarbon - genetics
Receptors, Aryl Hydrocarbon - metabolism
Signal Transduction
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Summary:Highlights • AHR links environmental clues to host immune responses. • AHR is activated by exogenous and endogenous ligands; their interplay is still poorly understood. • Different AHR ligands may differentially influence autoimmune diseases. • AHR signaling affects multiple immune cell types, including dendritic cells, T cells and innate lymphoid cells.
ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2015.10.002