Immune system transcriptome in gingival tissues of young nonhuman primates

Background and Objective Young/adolescent humans harbor many microorganisms associated with periodontal disease in adults and show substantial gingival inflammatory responses. However, younger individuals do not demonstrate the soft‐ and hard‐tissue destruction that hallmark periodontitis. Material...

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Bibliographic Details
Published in:Journal of periodontal research 2016-04, Vol.51 (2), p.152-163
Main Authors: Gonzalez, O. A., Nagarajan, R., Novak, M. J., Orraca, L., Gonzalez-Martinez, J. A., Kirakodu, S. S., Ebersole, J. L.
Format: Article
Language:English
Subjects:
aging
Animals
Gingiva
Immune System
inflammation
Macaca mulatta
nonhuman primates
Oligonucleotide Array Sequence Analysis
Periodontitis
Transcriptome
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Summary:Background and Objective Young/adolescent humans harbor many microorganisms associated with periodontal disease in adults and show substantial gingival inflammatory responses. However, younger individuals do not demonstrate the soft‐ and hard‐tissue destruction that hallmark periodontitis. Material and Methods This study evaluated responses to the oral microbial ecology in gingival tissues from clinically healthy young Macaca mulatta (
ISSN:0022-3484
1600-0765
DOI:10.1111/jre.12293