Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat

Highlights ► Bifenthrin decreases motor activity in rats peak 4 h post-exposure. ► Bifenthrin brain concentrations correlate with motoractivity independent of time. ► Bifenthrin blood concentrations correlations with motor activity are time dependent.

Saved in:
Bibliographic Details
Published in:Toxicology (Amsterdam) 2011-11, Vol.290 (1), p.1-6
Main Authors: Scollon, Edward J, Starr, James M, Crofton, Kevin M, Wolansky, Marcelo J, DeVito, Michael J, Hughes, Michael F
Format: Article
Language:English
Subjects:
administered dose
adults
Animals
Bifenthrin
Biological and medical sciences
blood
Blood concentrations
brain
Brain - drug effects
Brain - metabolism
Brain concentrations
corn oil
Emergency
exposure duration
high performance liquid chromatography
humans
Insecticides - blood
Insecticides - metabolism
Insecticides - toxicity
locomotion
Male
Medical sciences
Motor activity
Motor Activity - drug effects
Motor Activity - physiology
neurotoxicity
Pesticides, fertilizers and other agrochemicals toxicology
pharmacokinetics
prediction
pyrethrins
Pyrethrins - blood
Pyrethrins - metabolism
Pyrethrins - toxicity
Rats
Rats, Long-Evans
risk
Tissue Distribution - drug effects
Tissue Distribution - physiology
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights ► Bifenthrin decreases motor activity in rats peak 4 h post-exposure. ► Bifenthrin brain concentrations correlate with motoractivity independent of time. ► Bifenthrin blood concentrations correlations with motor activity are time dependent.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2011.08.002