Dynamics and role of antibodies to Plasmodium falciparum merozoite antigens in children living in two settings with differing malaria transmission intensity

Highlights • Antibody dynamics and role in young the infants’ low susceptibility to febrile malaria were investigated. • No evidence for association of antibody titres with clinical protection was found. • Evidence for consistently low antibody titres in high and low transmission areas. • Other anti...

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Bibliographic Details
Published in:Vaccine 2016-01, Vol.34 (1), p.160-166
Main Authors: Kangoye, David Tiga, Mensah, Victorine Atanase, Murungi, Linda Muthoni, Nkumama, Irene, Nebie, Issa, Marsh, Kevin, Cisse, Badara, Bejon, Philip, Osier, Faith Hope Among’in, Sirima, Sodiomon Bienvenu
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antibodies, Protozoan - blood
Antibody dynamics
Antigens
Antigens, Protozoan - immunology
Burkina Faso - epidemiology
Child
Child, Preschool
Children & youth
Disease transmission
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulins
Infant
Infants
Longitudinal Studies
Malaria
Malaria - epidemiology
Malaria - immunology
Malaria - transmission
Male
Medical research
Merozoite antigens
Merozoites - immunology
Parasites
Plasmodium falciparum
Plasmodium falciparum - immunology
Prospective Studies
Protective threshold
Rain
Senegal - epidemiology
Studies
Vaccines
Vector-borne diseases
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Summary:Highlights • Antibody dynamics and role in young the infants’ low susceptibility to febrile malaria were investigated. • No evidence for association of antibody titres with clinical protection was found. • Evidence for consistently low antibody titres in high and low transmission areas. • Other antibodies, other antibody-mediated mechanisms or other protecting factors may be operating.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.10.058