FARE-CAFE: a database of functional and regulatory elements of cancer-associated fusion events

Chromosomal translocation (CT) is of enormous clinical interest because this disorder is associated with various major solid tumors and leukemia. A tumor-specific fusion gene event may occur when a translocation joins two separate genes. Currently, various CT databases provide information about fusi...

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Bibliographic Details
Published in:Database : the journal of biological databases and curation 2015, Vol.2015, p.bav086
Main Authors: Korla, Praveen Kumar, Cheng, Jack, Huang, Chien-Hung, Tsai, Jeffrey J P, Liu, Yu-Hsuan, Kurubanjerdjit, Nilubon, Hsieh, Wen-Tsong, Chen, Huey-Yi, Ng, Ka-Lok
Format: Article
Language:English
Subjects:
Animals
Cancer
Databases, Genetic
DNA, Neoplasm - genetics
DNA, Neoplasm - metabolism
Genes
Humans
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Neoplasms - genetics
Neoplasms - metabolism
Original
Proteins
Response Elements
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Summary:Chromosomal translocation (CT) is of enormous clinical interest because this disorder is associated with various major solid tumors and leukemia. A tumor-specific fusion gene event may occur when a translocation joins two separate genes. Currently, various CT databases provide information about fusion genes and their genomic elements. However, no database of the roles of fusion genes, in terms of essential functional and regulatory elements in oncogenesis, is available. FARE-CAFE is a unique combination of CTs, fusion proteins, protein domains, domain-domain interactions, protein-protein interactions, transcription factors and microRNAs, with subsequent experimental information, which cannot be found in any other CT database. Genomic DNA information including, for example, manually collected exact locations of the first and second break points, sequences and karyotypes of fusion genes are included. FARE-CAFE will substantially facilitate the cancer biologist's mission of elucidating the pathogenesis of various types of cancer. This database will ultimately help to develop 'novel' therapeutic approaches. Database URL: http://ppi.bioinfo.asia.edu.tw/FARE-CAFE.
ISSN:1758-0463
1758-0463
DOI:10.1093/database/bav086