Cortical specificity in neurovascular coupling

Despite mounting contrary evidence, the metabolic hypothesis is viewed as the predominant theory underlying neurovascular coupling, or the link between neural activity and cerebral blood flow. In a recent study, Huo et al. (Huo BX, Smith JB, Drew PJ. J Neurosci 34: 10975-10981, 2014) combined multim...

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Bibliographic Details
Published in:Journal of neurophysiology 2015-12, Vol.114 (6), p.3031-3032
Main Author: Scott, Nadia Aleyna
Format: Article
Language:English
Subjects:
Animals
Cerebrovascular Circulation
Hemodynamics
Mice
Neuro Forum
Neurovascular Coupling
Wakefulness
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Summary:Despite mounting contrary evidence, the metabolic hypothesis is viewed as the predominant theory underlying neurovascular coupling, or the link between neural activity and cerebral blood flow. In a recent study, Huo et al. (Huo BX, Smith JB, Drew PJ. J Neurosci 34: 10975-10981, 2014) combined multimodal imaging and electrophysiology in experiments using awake, voluntarily moving mice to explore whether neurovascular coupling is uniform throughout the cortex. Whereas their results can be viewed as demonstrating that neural activity and blood flow are uncoupled in the frontal cortex during movement, the importance of this study is the elucidation that the metabolic hypothesis may not be the principle facilitator of neurovascular coupling in some regions of the cortex.
ISSN:0022-3077
1522-1598
DOI:10.1152/jn.00915.2014