TERT promoter mutations and monoallelic activation of TERT in cancer

Here we report that promoter mutations in telomerase ( TERT ), the most common noncoding mutations in cancer, give rise to monoallelic expression of TERT . Through deep RNA sequencing, we find that TERT activation in human cancer cell lines can occur in either mono- or biallelic manner. Without exce...

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Bibliographic Details
Published in:Oncogenesis (New York, NY) NY), 2015-12, Vol.4 (12), p.e176-e176
Main Authors: Huang, F W, Bielski, C M, Rinne, M L, Hahn, W C, Sellers, W R, Stegmeier, F, Garraway, L A, Kryukov, G V
Format: Article
Language:English
Subjects:
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Apoptosis
Cell Biology
Human Genetics
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Short Communication
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Summary:Here we report that promoter mutations in telomerase ( TERT ), the most common noncoding mutations in cancer, give rise to monoallelic expression of TERT . Through deep RNA sequencing, we find that TERT activation in human cancer cell lines can occur in either mono- or biallelic manner. Without exception, hotspot TERT promoter mutations lead to the re-expression of only one allele, accounting for approximately half of the observed cases of monoallelic TERT expression. Furthermore, we show that monoallelic TERT expression is highly prevalent in certain tumor types and widespread across a broad spectrum of cancers. Taken together, these observations provide insights into the mechanisms of TERT activation and the ramifications of noncoding mutations in cancer.
ISSN:2157-9024
2157-9024
DOI:10.1038/oncsis.2015.39