Impact of Chromatin on HIV Replication

Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin structure and organization and that also impact HIV integration, transcriptional regulation and latency. Furthermore, recent attempts to target c...

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Bibliographic Details
Published in:Genes 2015-09, Vol.6 (4), p.957-976
Main Authors: Agosto, Luis M, Gagne, Matthew, Henderson, Andrew J
Format: Article
Language:English
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Review
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Summary:Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin structure and organization and that also impact HIV integration, transcriptional regulation and latency. Furthermore, recent attempts to target chromatin associated factors to reduce the HIV proviral load are discussed.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes6040957