Role of S180L polymorphism in etiology of malaria caused by Plasmodium falciparum in a small group of Pakistani population

The aim of our study was to investigate the role of S180L polymorphism in modulation of acquisition of malaria caused by Plasmodium falciparum in a small group of Pakistani population. A total of 133 individuals including 60 controls and 73 patients of malaria, caused by Plasmodium falciparum, were...

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Bibliographic Details
Published in:Biomolecules & biomedicine 2015-08, Vol.15 (4), p.20-23
Main Authors: Nawaz, Syed Kashif, Ahmed, Bisma, Arshad, Najma, Rani, Asima, Rasool, Hamadia, Arshad, Muhammad
Format: Article
Language:English
Subjects:
Adult
Aged
Alleles
Analysis
Anopheles
Case-Control Studies
Development and progression
Female
Gene Frequency
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Heterozygote
Humans
Malaria
Malaria, Falciparum - epidemiology
Malaria, Falciparum - genetics
Male
Membrane Glycoproteins - genetics
Pakistan - epidemiology
Plasmodium falciparum
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Receptors, Interleukin-1 - genetics
Young Adult
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Summary:The aim of our study was to investigate the role of S180L polymorphism in modulation of acquisition of malaria caused by Plasmodium falciparum in a small group of Pakistani population. A total of 133 individuals including 60 controls and 73 patients of malaria, caused by Plasmodium falciparum, were genotyped using allele-specific PCR. Ninety-two samples successfully demonstrated the PCR amplification results, while forty-one samples could not be genotyped due to failure in PCR amplification. The allele frequency for S180L polymorphism was deviant from Hardy-Weinberg equilibrium (HWE) of the population under observation. Association was found between the observed polymorphism and the occurrence of malaria caused by Plasmodium falciparum (p = 0.01). Chances of malaria caused by Plasmodium falciparum were low in CC genotype carriers in comparison to other genotypes (Odds ratio: 0.3016; 95% CI: 0.124-0.729). The present findings suggest that S180L polymorphism is important in modulating the probability of acquisition of malaria caused by Plasmodium falciparum in Pakistani population. The CC genotype plays a protective role in local population against this type of malaria.
ISSN:2831-0896
1512-8601
1840-4812
2831-090X
DOI:10.17305/bjbms.2015.413