MicroRNA expression is altered in lateral septum across reproductive stages

Highlights • A subset of up and downregulated miRNAs are a component of the maternal brain. • A number of miRNAs downregulated during female reproduction are located in 12qF1 region that includes the Dlk1-Dio3 cluster. • Reproductive miRNA gene targets are highly enriched for genes involved in trans...

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Bibliographic Details
Published in:Neuroscience 2016-01, Vol.312, p.130-140
Main Authors: Saul, M.C, Zhao, C, Driessen, T.M, Eisinger, B.E, Gammie, S.C
Format: Article
Language:English
Subjects:
14q32
Animals
Chromosomes, Mammalian - genetics
Dlk1-Dio3
Down-Regulation
Female
Gene Expression - physiology
Gene Expression Regulation - physiology
Humans
Intercellular Signaling Peptides and Proteins - genetics
Iodide Peroxidase - genetics
lateral septum
Male
maternal
Mice
Mice, Inbred ICR
microRNA
MicroRNAs - metabolism
Neurology
postpartum
Postpartum Period - metabolism
Pregnancy
Reproduction - physiology
Septal Nuclei - metabolism
Sequence Analysis, RNA
Up-Regulation
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Summary:Highlights • A subset of up and downregulated miRNAs are a component of the maternal brain. • A number of miRNAs downregulated during female reproduction are located in 12qF1 region that includes the Dlk1-Dio3 cluster. • Reproductive miRNA gene targets are highly enriched for genes involved in transcriptional regulation. • Reproductive miRNA gene targets are consistent with known postpartum gene expression changes across multiple CNS regions. • A new research tool provides enrichment analysis of large-scale gene expression datasets against large target datasets.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.11.019