Comprehensive analytical model for CW laser induced heat in turbid media

In this work, we present a new analytical approach to model continuous wave laser induced temperature in highly homogeneous turbid media. First, the diffusion equation is used to model light transport and a comprehensive solution is derived analytically by obtaining a special Greens' function....

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Bibliographic Details
Published in:Optics express 2015-11, Vol.23 (24), p.31069-31084
Main Authors: Erkol, Hakan, Nouizi, Farouk, Luk, Alex, Unlu, Mehmet Burcin, Gulsen, Gultekin
Format: Article
Language:English
Subjects:
Animals
Body Temperature - physiology
Body Temperature - radiation effects
Breast - physiology
Breast - radiation effects
Chickens
Computer Simulation
Lasers
Models, Biological
Nephelometry and Turbidimetry - methods
Scattering, Radiation
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Summary:In this work, we present a new analytical approach to model continuous wave laser induced temperature in highly homogeneous turbid media. First, the diffusion equation is used to model light transport and a comprehensive solution is derived analytically by obtaining a special Greens' function. Next, the time-dependent bio-heat equation is used to describe the induced heat increase and propagation within the medium. The bio-heat equation is solved analytically utilizing the separation of variables technique. Our theoretical model is successfully validated using numerical simulations and experimental studies with agarose phantoms and ex-vivo chicken breast samples. The encouraging results show that our method can be implemented as a simulation tool to determine important laser parameters that govern the magnitude of temperature rise within homogenous biological tissue or organs.
ISSN:1094-4087
1094-4087
DOI:10.1364/OE.23.031069