Evaluation of Amniotic Membrane Effectiveness in Skin Graft Donor Site Dressing in Burn Patients

• Published in: Indian journal of surgery 2015-12, Vol.77 (Suppl 2), p.427-431
• Main Authors: Salehi, Seyed Hamid, As’adi, Kamran, Mousavi, Seyed Jaber, Shoar, Saeed
• Format: Article
• Language: English
• Subjects: Analysis; Burn treatment; Burns; Cardiac Surgery; Clinical outcomes; Health aspects; Medicine; Medicine & Public Health; Membranes; Neurosurgery; Original; Original Article; Pediatric Surgery; Plastic Surgery; Political corruption; Skin; Skin & tissue grafts; Surgery; Thoracic Surgery; Wound care; Wound healing
• ISSN: 0972-2068; 0973-9793
• DOI: 10.1007/s12262-013-0864-x

Although the recipient site in burn wounds is dressed with universally accepted materials, the ideal management of split-thickness skin donor sites remains controversial. The aim of our study is to compare two methods of wound dressing in donor sites of split-thickness skin graft in patients undergoing burn wound reconstructive surgery. Forty-two consecutive patients with second- and third-degree burns with a total body surface area between 20 and 40 % were enrolled in this randomized clinical trial conducted in Motahari Burn Hospital in Tehran, Iran. In each patient, two anatomic areas with similar features were randomly selected as intervention and control donor sites. The intervention site was dressed with amniotic membrane, whereas the control site was treated with Vaseline-impregnated gauze. Wounds were examined daily by expert surgeons to measure the clinical outcomes including duration of healing, severity of pain, and infection rate. The mean ± SD age of patients was 31.17 ± 13.72 years; furthermore, burn percentage had a mean ± SD of 31.19 ± 10.56. The mean ± SD of patients' cooperation score was 1.6 ± 0.79 in the intervention group compared with 2.93 ± 0.71 in the control group, revealing a statistically significant difference ( P