Changes in platelet function following cold storage of RBC suspensions

To provide a basis for the cold-storage of human platelets as a way to assess changes in platelet function. Red blood cell suspensions (11 U and 50 U) were randomly selected at different storage times (3-28 days) and evidence of platelet activation (CD62P) and thromboelastography (TEG) reaction time...

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Published in:International journal of clinical and experimental medicine 2015-01, Vol.8 (10), p.18066-18073
Main Authors: Dang, Qian-Li, Li, Jian-Gang, Sun, Yang, Jin, Zhan-Kui, Gao, Ying, Xu, Cui-Xiang, Chen, Ping, Ma, Ting, Yang, Jiang-Cun
Format: Article
Language:English
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Summary:To provide a basis for the cold-storage of human platelets as a way to assess changes in platelet function. Red blood cell suspensions (11 U and 50 U) were randomly selected at different storage times (3-28 days) and evidence of platelet activation (CD62P) and thromboelastography (TEG) reaction times were investigated. After 21 days of storage at 4°C, a large number of activated platelets (PAC1+62P+, PAC1-62P+) within the red blood cell suspension (RBCs) retained their function and had TEG-maximum amplitude (TEG-MA) indices in the normal range. We report that platelets in RBC suspensions retain high activity when stored at 4°C for 21 days. The results provide important information for studies that involve storing platelets under cold conditions.
ISSN:1940-5901
1940-5901